Evidence map›Paper›PMID 38700596›Full record

ArticleInternational ophthalmology2024

Whole-orbit-based multiparametric assessment of disease activity of thyroid eye disease on Dixon MRI.

Duojin Xia, Haiyang Zhang, Hui Wang, Mengda Jiang, Yan Tang, Yinwei Li, Jing Sun, Xuefei Song, Huifang Zhou

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In one paragraph

Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Duojin Xia *School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Haiyang Zhang *Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and ocularoncology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Hui WangDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and ocularoncology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Mengda JiangDepartment of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yan TangDepartment of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yinwei LiDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and ocularoncology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Jing SunDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and ocularoncology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Xuefei SongDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Orbital Diseases and ocularoncology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. songxuefei@shsmu.edu.cn.
Huifang ZhouSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China. fangzzfang@sjtu.edu.cn.

Funding

Clinical Research Program of 9th People's Hospital, Shanghai Jiao Tong University School of Medicine JYLJ202120the Clinical Acceleration Program of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine JYLJ202202the National Natural Science Foundation of China 82071003 and 82271122the Science and Technology Commission of Shanghai 20DZ22708the Shanghai Key Clinical Specialty, Shanghai Eye Disease Research Center 2022ZZ01003
6 · The paper itself

Abstract

purposeThis study aimed to explore the diagnostic value of whole-orbit-based multiparametric assessment on Dixon MRI for the evaluation of the thyroid eye disease (TED) activity.

methodsThe retrospective study enrolled patients diagnosed as TED and obtained their axial and coronal Dixon MRI scans. Multiparameters were assessed, including water fraction (WF), fat fraction (FF) of extraocular muscles (EOMs), orbital fat (OF), and lacrimal gland (LG). The thickness of OF and herniation of LG were also measured. Univariable and multivariable logistic regression was applied to construct prediction models based on single or multiple structures. Receiver operating characteristic (ROC) curve analysis was also implemented.

resultsUnivariable logistic analysis revealed significant differences in water fraction (WF) of the superior rectus (P = 0.018), fat fraction (FF) of the medial rectus (P = 0.029), WF of OF (P = 0.004), and herniation of LG (P = 0.012) between the active and inactive TED phases. Multivariable logistic analysis and corresponding receiver operating characteristic curve (ROC) analysis of each structure attained the area under the curve (AUC) values of 0.774, 0.771, and 0.729 for EOMs, OF, and LG, respectively, while the combination of the four imaging parameters generated a final AUC of 0.909.

conclusionsDixon MRI may be used for fine multiparametric assessment of multiple orbital structures. The whole-orbit-based model improves the diagnostic performance of TED activity evaluation.

Indexed as

Graves OphthalmopathyOculomotor MusclesOrbitROC CurveAdultAgedFemaleHumansLacrimal ApparatusMagnetic Resonance ImagingMaleMiddle AgedMultiparametric Magnetic Resonance ImagingRetrospective StudiesDixon MRIMagnetic resonance imagingQuantitative multiple parametersThyroid eye diseaseWhole orbit

Identifiers

PMID38700596

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