Evidence map›Paper›PMID 38700338›Full record

ArticlemSystems2024

Association between gut microbiota dysbiosis and poor functional outcomes in acute ischemic stroke patients with COVID-19 infection.

Jiaying Chen, Xuxuan Gao, Jingru Liang, Qiheng Wu, Linlin Shen, Yifeng Zheng, Yu Ma, Yuping Peng, Yan He, Jia Yin

Abstract read
In one paragraph

Article in mSystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. A long journey to treat epilepsy with the gut microbiota.Frontiers in cellular neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaying Chen *Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xuxuan Gao *Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jingru Liang *Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Qiheng WuDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Linlin ShenDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yifeng ZhengDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yu MaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yuping PengDepartment of Neurosurgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.ORCID 0000-0002-5966-0922
Yan HeMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0002-6611-2959
Jia YinDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0001-8944-6604

Funding

China Postdoctoral Science Foundation (China Postdoctoral Foundation Project) 2022M721496GDSTC | Natural Science Foundation of Guangdong Province 2022A1515010477Guangdong Provincial Key Laboratory of Innovation Method and Decision Management System (Guangdong Key Laboratory of Innovation Method and Decision Management System) 202206060001MOST | National Natural Science Foundation of China (NSFC) NSFC82171317
6 · The paper itself

Abstract

Acute ischemic stroke (AIS) patients with active COVID-19 infection often have more severe symptoms and worse recovery. COVID-19 infection can cause gut microbiota dysbiosis, which is also a risk factor for poor outcomes in AIS patients. However, the association between gut microbiota and functional outcomes among AIS patients with COVID-19 infection has not been fully clarified yet. In this study, we performed 16S rRNA gene sequencing to characterize the gut microbial community among AIS patients with acute COVID-19 infection, AIS patients with post-acute COVID-19 infection, and AIS patients without COVID-19 infection. We found that AIS patients with acute COVID-19 experienced poorer recovery and significant gut dysbiosis, characterized by higher levels of

Indexed as

COVID-19DysbiosisGastrointestinal MicrobiomeIschemic StrokeAgedFemaleHumansMaleMiddle AgedRisk FactorsRNA, Ribosomal, 16SSARS-CoV-2RNA, Ribosomal, 16SCOVID-19dysbiosisfunctional outcomesgut microbiotastroke

Identifiers

PMID38700338
PMCPMC11237522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.