Evidence map›Paper›PMID 38700325›Full record

ArticlemBio2024

Counterclockwise rotation of the flagellum promotes biofilm initiation in

Xiaolin Liu, Paphavee Lertsethtakarn, Vanessa T Mariscal, Fitnat Yildiz, Karen M Ottemann

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Characterization ofJournal of bacteriology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Pathogenicity ofWorld journal of clinical oncology · 2025
    Review
  7. Article
  8. Load-dependent resistive-force theory for helical filaments.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Article
  9. Article
  10. Article
  11. Molecular Mechanisms of Biofilm Formation inAntibiotics (Basel, Switzerland) · 2024
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaolin LiuDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.ORCID 0000-0001-5891-4559
Paphavee LertsethtakarnDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.
Vanessa T MariscalDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.
Fitnat YildizDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.ORCID 0000-0002-6384-7167
Karen M OttemannDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.ORCID 0000-0001-6265-7401

Funding

The function of chemotactic signal transduction during colonization and diseaseR01AI116946 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI OTTEMANN, KAREN M · 2016 to 2025
$5.1M
Understanding and manipulating chronic Helicobacter pylori to enhance treatmentR01AI164682 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI OTTEMANN, KAREN M · 2021 to 2025
$2.0M
China Scholarship Council (CSC) 201904910692HHS | National Institutes of Health (NIH) AI164682NIAID NIH HHS R01 AI116946NIAID NIH HHS R01 AI164682
6 · The paper itself

Abstract

Motility promotes biofilm initiation during the early steps of this process: microbial surface association and attachment. Motility is controlled in part by chemotaxis signaling, so it seems reasonable that chemotaxis may also affect biofilm formation. There is a gap, however, in our understanding of the interactions between chemotaxis and biofilm formation, partly because most studies analyzed the phenotype of only a single chemotaxis signaling mutant, e.g., IMPORTANCE: Chemotaxis signaling systems have been reported to contribute to biofilm formation in many bacteria; however, how they regulate biofilm formation remains largely unknown. Chemotaxis systems are composed of many distinct kinds of proteins, but most previous work analyzed the biofilm effect of loss of only a few. Here, we explored chemotaxis' role during biofilm formation in the human-associated pathogenic bacterium

Indexed as

Bacterial ProteinsBiofilmsChemotaxisFlagellaHelicobacter pyloriMutationRotationSignal TransductionBacterial Proteinsbiofilm initiationchemotaxisflagellar rotationH. pylori

Identifiers

PMID38700325
PMCPMC11237671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.