Evidence map›Paper›PMID 38700101›Full record

Trial reportThe Journal of infectious diseases2024

Drug Concentrations in Hair and Dried Blood Spots as Preexposure Prophylaxis Adherence Metrics During Pregnancy and Postpartum.

Linxuan Wu, John Kinuthia, Peter L Anderson, Jared M Baeten, Julia C Dettinger, Monica Gandhi, Laurén Gomez, Grace John-Stewart, Mary M Marwa, Nancy Ngumbau and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Linxuan WuDepartment of Epidemiology, University of Washington, Seattle.
John KinuthiaDepartment of Global Health, University of Washington, Seattle.
Peter L AndersonDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora.
Jared M BaetenDepartment of Epidemiology, University of Washington, Seattle.
Julia C DettingerDepartment of Global Health, University of Washington, Seattle.
Monica GandhiDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco.ORCID 0000-0002-7025-1994
Laurén GomezDepartment of Epidemiology, University of Washington, Seattle.
Grace John-StewartDepartment of Epidemiology, University of Washington, Seattle.ORCID 0000-0002-4301-1573
Mary M MarwaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Nancy NgumbauDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Felix OtienoDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Pascal OmondiDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Ben OdhiamboDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Salphine WatoyiDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Jillian PintyeDepartment of Global Health, University of Washington, Seattle.ORCID 0000-0003-1255-7191

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention TrialsR01AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2012 to 2021
$5.6M
Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING-PUMA)R01AI143340 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2018 to 2026
$5.6M
Delivering PrEP in PregnancyR01AI125498 · NIAID · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2016 to 2020
$3.6M
Evaluating Infant PrEP Exposure During Pregnancy and BreastfeedingR01HD100201 · NICHD · UNIVERSITY OF WASHINGTON · PI PINTYE, JILLIAN · 2019 to 2023
$3.4M
PrEP optimized for mothers (PrOM): efficient PrEP integration in MCH clinicsR01HD094630 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2017 to 2021
$3.3M
Evaluating sexually transmitted infections among adolescent girls and young women within a pharmacy-based PrEP delivery model in Kenya.R01HD108041 · NICHD · UNIVERSITY OF WASHINGTON · PI BUKUSI, ELIZABETH ANNE, PINTYE, JILLIAN · 2021 to 2025
$3.3M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
mWACh-PrEP: A SMS-based Support Intervention to Enhance PrEP Adherence during Pregnancy and BreastfeedingR01NR019220 · NINR · UNIVERSITY OF WASHINGTON · PI KINUTHIA, JOHN, PINTYE, JILLIAN · 2020 to 2024
$2.9M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD094630Global Center for the Integrated Health of Women, Adolescents, and ChildrenNational Institute of Allergy and Infectious Disease R01AI125498NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI098472NIAID NIH HHS R01 AI125498NIAID NIH HHS R37 AI098472NICHD NIH HHS R01 HD094630NICHD NIH HHS R01 HD100201NICHD NIH HHS R01 HD108041NICHD NIH HHS R01HD108041NIH HHSNINR NIH HHS R01 NR019220NINR NIH HHS R01NR019220University of Washington's Center for AIDS Research Behavioral Sciences Core and Biometrics Core P30AI027757
6 · The paper itself

Abstract

We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV preexposure prophylaxis during pregnancy and postpartum and compared hair levels with TFV-diphosphate levels in dried blood spots (DBSs). Overall 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster-randomized trial. Having a partner with HIV was associated with higher hair TFV levels (P < .001). Hair TFV concentrations were strongly correlated with DBS TFV-diphosphate levels (r = 0.76, P < .001), indicating hair as a promising cumulative adherence metric for perinatal preexposure prophylaxis assessment.

Indexed as

Anti-HIV AgentsHairHIV InfectionsPostpartum PeriodPre-Exposure ProphylaxisTenofovirAdenineAdultDried Blood Spot TestingDrug MonitoringFemaleHumansOrganophosphatesPregnancyPregnancy Complications, InfectiousYoung AdultAdenineAnti-HIV AgentsOrganophosphatesTenofovirtenofovir diphosphatehairHIVpostpartumpregnancyPrEP

Identifiers

PMID38700101
PMCPMC11420739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.