Evidence map›Paper›PMID 38700095›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Diffuse optical tomography for mapping cerebral hemodynamics and functional connectivity in delirium.

Shixie Jiang, Jingyu Huang, Hao Yang, Richard Czuma, Lauren Farley, Alexis Cohen-Oram, Kimberly Hartney, Kristina Chechotka, F Andrew Kozel, Huabei Jiang

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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Diffuse optical tomography for mapping cerebral hemodynamics and functional connectivity in delirium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shixie JiangDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, Florida, USA.
Jingyu HuangDepartment of Medical Engineering, University of South Florida, Tampa, Florida, USA.
Hao YangDepartment of Medical Engineering, University of South Florida, Tampa, Florida, USA.
Richard CzumaDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, Florida, USA.
Lauren FarleyDepartment of Surgery and Division of Vascular Surgery, University of South Florida, Tampa, Florida, USA.
Alexis Cohen-OramDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, Florida, USA.
Kimberly HartneyDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, Florida, USA.
Kristina ChechotkaDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, Florida, USA.
F Andrew KozelDepartment of Behavioral Sciences and Social Medicine, Florida State University, Tallahassee, Florida, USA.
Huabei JiangDepartment of Medical Engineering, University of South Florida, Tampa, Florida, USA.

Funding

University of South Florida internal department funds
6 · The paper itself

Abstract

introductionDelirium is associated with mortality and new onset dementia, yet the underlying pathophysiology remains poorly understood. Development of imaging biomarkers has been difficult given the challenging nature of imaging delirious patients. Diffuse optical tomography (DOT) offers a promising approach for investigating delirium given its portability and three-dimensional capabilities.

methodsTwenty-five delirious and matched non-delirious patients (n = 50) were examined using DOT, comparing cerebral oxygenation and functional connectivity in the prefrontal cortex during and after an episode of delirium.

resultsTotal hemoglobin values were significantly decreased in the delirium group, even after delirium resolution. Functional connectivity between the dorsolateral prefrontal cortex and dorsomedial prefrontal cortex was strengthened post-resolution compared to during an episode; however, this relationship was still significantly weaker compared to controls. DISCUSSION: These findings highlight DOT's potential as an imaging biomarker to measure impaired cerebral oxygenation and functional dysconnectivity during and after delirium. Future studies should focus on the role of cerebral oxygenation in delirium pathogenesis and exploring the etiological link between delirium and dementias. HIGHLIGHTS: We developed a portable diffuse optical tomography (DOT) system for bedside three-dimensional functional neuroimaging to study delirium in the hospital. We implemented a novel DOT task-focused seed-based correlation analysis. DOT revealed decreased cerebral oxygenation and functional connectivity strength in the delirium group, even after resolution of delirium.

Indexed as

DeliriumTomography, OpticalAgedBrain MappingCerebrovascular CirculationFemaleHemodynamicsHumansMaleMiddle AgedPrefrontal Cortexacute brain failuredeliriumdiffuse optical tomographyencephalopathynear‐infrared lightoptical imaging

Identifiers

PMID38700095
PMCPMC11180861

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.