Evidence map›Paper›PMID 38700066›Full record

ArticleClinical and experimental immunology2024

NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment.

Luciana Polaco Covre, Carlos Henrique Fantecelle, Ariadne Mendes Queiroz, Julia Miranda Fardin, Pedro Henrique Miranda, Sian Henson, Alessandra Marcia da Fonseca-Martins, Herbert Leonel de Matos Guedes, David Mosser, Aloisio Falqueto and 2 more

Abstract read
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In one paragraph

Article in Clinical and experimental immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Luciana Polaco CovreNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
Carlos Henrique FantecelleNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
Ariadne Mendes QueirozNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
Julia Miranda FardinNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.
Pedro Henrique MirandaNúcleo de Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Brazil.
Sian HensonTranslational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Alessandra Marcia da Fonseca-MartinsInstituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Herbert Leonel de Matos GuedesInstituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
David MosserDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Aloisio FalquetoDepartamento de Medicina Social, Universidade Federal do Espírito Santo, Vitória, Brazil.
Arne AkbarInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Daniel Claudio Oliveira GomesNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil.ORCID 0000-0002-0663-0981

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro FAPERJ-PDS-2023Medical Research Council (UK) MR/T015853/1National Council for Scientific and Technological Development-CNPQ 200222/2022-8
6 · The paper itself

Abstract

Natural killer (NK) cells include different subsets with diverse effector capacities that are poorly understood in the context of parasitic diseases. Here, we investigated inhibitory and activating receptor expression on NK cells in patients with cutaneous leishmaniasis (CL) and explored their phenotypic and functional heterogeneity based on CD57 and NKG2C expression. The expression of CD57 identified NK cells that accumulated in CL patients and exhibited features of senescence. The CD57+ cells exhibited heightened levels of the activating receptor NKG2C and diminished expression of the inhibitory receptor NKG2A. RNA sequencing analyses based on NKG2C transcriptome have revealed two distinct profiles among CL patients associated with cytotoxic and functional genes. The CD57+NKG2C+ subset accumulated in the blood of patients and presented conspicuous features of senescence, including the expression of markers such as p16, yH2ax, and p38, as well as reduced proliferative capacity. In addition, they positively correlated with the number of days until lesion resolution. This study provides a broad understanding of the NK cell biology during Leishmania infection and reinforces the role of senescent cells in the adverse clinical outcomes of CL.

Indexed as

CD57 AntigensCellular SenescenceKiller Cells, NaturalLeishmaniasis, CutaneousNK Cell Lectin-Like Receptor Subfamily CAdultFemaleHumansMaleMiddle AgedYoung AdultCD57 AntigensKLRC2 protein, humanNK Cell Lectin-Like Receptor Subfamily Ccellular senescencecutaneous leishmaniasisimmunopathologylesional healingNK cells

Identifiers

PMID38700066
PMCPMC11310703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.