Evidence map›Paper›PMID 38700013›Full record

ArticleJournal of the American Heart Association2024

Sex Differences in Cardiovascular Outcomes in Patients With Kidney Failure.

Silvi Shah, Annette L Christianson, Karthikeyan Meganathan, Anthony C Leonard, Deidra C Crews, Jack Rubinstein, Mark M Mitsnefes, Daniel P Schauer, Charuhas V Thakar

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Sex-Specific Outcomes in the Peritoneal Dialysis Outcomes and Practice Patterns Study.Clinical journal of the American Society of Nephrology : CJASN · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvi ShahDivision of Nephrology and Hypertension, Department of Internal Medicine University of Cincinnati Cincinnati OH USA.ORCID 0000-0002-9941-9404
Annette L ChristiansonDepartment of Environmental Health University of Cincinnati Cincinnati OH USA.
Karthikeyan MeganathanDepartment of Environmental Health University of Cincinnati Cincinnati OH USA.
Anthony C LeonardDepartment of Environmental Health University of Cincinnati Cincinnati OH USA.ORCID 0000-0003-2193-8084
Deidra C CrewsDivision of Nephrology, Department of Medicine Johns Hopkins University School of Medicine Baltimore MD USA.ORCID 0000-0003-3425-5776
Jack RubinsteinDivision of Cardiology, Department of Internal Medicine University of Cincinnati Cincinnati OH USA.ORCID 0000-0002-8811-1551
Mark M MitsnefesDivision of Nephrology and Hypertension Cincinnati Children's Hospital Medical Center Cincinnati OH USA.ORCID 0000-0002-9904-0250
Daniel P SchauerDivision of General Internal Medicine and Center for Clinical Effectiveness University of Cincinnati Cincinnati OH USA.ORCID 0000-0003-3264-8154
Charuhas V ThakarDivision of Nephrology and Hypertension, Department of Internal Medicine University of Cincinnati Cincinnati OH USA.

Funding

Sex Disparities in Cardiovascular Disease and Optimal Coronary Revascularization in Dialysis PatientsK23HL151816 · NHLBI · UNIVERSITY OF CINCINNATI · PI SHAH, SILVI · 2021 to 2025
$1.0M
Patient-Oriented Research Addressing Disparities in Hypertension and Kidney DiseaseK24HL148181 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CREWS, DEIDRA CANDICE · 2019 to 2023
$541k
NHLBI NIH HHS K23 HL151816NHLBI NIH HHS K24 HL148181
6 · The paper itself

Abstract

backgroundCardiovascular disease is the leading cause of mortality in patients with kidney failure, and their risk of cardiovascular events is 10 to 20 times higher as compared with the general population. METHODS AND

resultsWe evaluated 508 822 patients who initiated dialysis between January 1, 2005 and December 31, 2014 using the United States Renal Data System with linked Medicare claims. We determined hospitalization rates for cardiovascular events, defined by acute coronary syndrome, heart failure, and stroke. We examined the association of sex with outcome of cardiovascular events, cardiovascular death, and all-cause death using adjusted time-to-event models. The mean age was 70±12 years and 44.7% were women. The cardiovascular event rate was 232 per thousand person-years (95% CI, 231-233), with a higher rate in women than in men (248 per thousand person-years [95% CI, 247-250] versus 219 per thousand person-years [95% CI, 217-220]). Women had a 14% higher risk of cardiovascular events than men (hazard ratio [HR], 1.14 [95% CI, 1.13-1.16]). Women had a 16% higher risk of heart failure (HR, 1.16 [95% CI, 1.15-1.18]), a 31% higher risk of stroke (HR, 1.31 [95% CI, 1.28-1.34]), and no difference in risk of acute coronary syndrome (HR, 1.01 [95% CI, 0.99-1.03]). Women had a lower risk of cardiovascular death (HR, 0.89 [95% CI, 0.88-0.90]) and a lower risk of all-cause death than men (HR, 0.96 [95% CI, 0.95-0.97]).

conclusionsAmong patients undergoing dialysis, women have a higher risk of cardiovascular events of heart failure and stroke than men. Women have a lower adjusted risk of cardiovascular mortality and all-cause mortality.

Indexed as

Cardiovascular DiseasesCause of DeathAcute Coronary SyndromeAgedAged, 80 and overFemaleHeart FailureHospitalizationHumansKidney Failure, ChronicMaleMedicareMiddle AgedRenal DialysisRenal InsufficiencyRetrospective Studiescardiovascular eventsdeathdialysisdisparitiessex

Identifiers

PMID38700013
PMCPMC11179932

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.