SynthesisJournal of the American Heart Association2024
Moderate Aortic Valve Stenosis Is Associated With Increased Mortality Rate and Lifetime Loss: Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data of 409 680 Patients.
Synthesis in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Impact of Concomitant Mitral Regurgitation in Moderate Aortic Stenosis: Assessment of Remodeling and Clinical Outcomes.JACC. Cardiovascular imaging · 2026Article
- Type 2 diabetes is associated with clinical progression of aortic stenosis: a nationwide retrospective study in Sweden.Scientific reports · 2026Article
- Analysis of the Accuracy and Inter-Reader Precision of Scar Quantification Techniques in Aortic Stenosis: A Comparative Cardiovascular Magnetic Resonance Imaging Study.Diagnostics (Basel, Switzerland) · 2026Article
- Heart Failure and Moderate Aortic Stenosis: is Early TAVI the Better Strategy?European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Article
- Clinical risk score for cardiac death or heart failure hospitalization in moderate aortic stenosis.Echo research and practice · 2026Article
- Evolution of Cardiac Damage Across Clinically Defined Stages of Aortic Stenosis in Patients Undergoing TAVR: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Precision RNA interference of Smad3 and Runx2 via dual targeting nanocarriers mitigates aortic valve disease.Journal of translational medicine · 2026Article
- Clinical, Echocardiographic, and Socioeconomic Predictors of Progression and Outcomes in Patients With Moderate Aortic Stenosis.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Women With Moderate or Severe Aortic Stenosis by Aortic Valve Area Are Disproportionately Classified With Normal-Flow Low-Gradient Aortic Stenosis and Assigned Lower Severity Grades Than Men.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus.Aging and disease · 2025Article
- Design and Optimization of a Tapered Magnetic Soft Continuum Robot for Enhanced Navigation in Cerebral Vasculature.Micromachines · 2025Article
- Racial and ethnic disparities in aortic stenosis within a universal healthcare system characterized by natural language processing for targeted intervention.European heart journal. Digital health · 2025Article
- Utility of Serum Biomarkers of Myocardial Fibrosis in High-Gradient Severe Aortic Stenosis: An Explorative Cardiovascular Magnetic Resonance Imaging-Based Study.Diagnostics (Basel, Switzerland) · 2025Article
- Multimodal deep learning model for enhanced early detection of aortic stenosis integrating ECG and chest x-ray with cooperative learning.Frontiers in radiology · 2025Article
- Clinical Outcomes According to Aortic Stenosis Management: Insights From Real-World Practice.Journal of the American Heart Association · 2024Article
- Quantification of Replacement Fibrosis in Aortic Stenosis: A Narrative Review on the Utility of Cardiovascular Magnetic Resonance Imaging.Diagnostics (Basel, Switzerland) · 2024Review
- Toward a Holistic Approach in Aortic Stenosis Using Machine-Learning Algorithms.JACC. Advances · 2024Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mortality risk attributable to moderate aortic stenosis (AS) remains incompletely characterized and has historically been underestimated. We aim to evaluate the association between moderate AS and all-cause death, comparing it with no/mild AS (in a general referral population and in patients with heart failure with reduced ejection fraction). METHODS AND
resultsA systematic review and pooled meta-analysis of Kaplan-Meier-derived reconstructed time-to-event data of studies published by June 2023 was conducted to evaluate survival outcomes among patients with moderate AS in comparison with individuals with no/mild AS. Ten studies were included, encompassing a total of 409 680 patients (11 527 with moderate AS and 398 153 with no/mild AS). In the overall population, the 15-year overall survival rate was 23.3% (95% CI, 19.1%-28.3%) in patients with moderate AS and 58.9% (95% CI, 58.1%-59.7%) in patients with no/mild aortic stenosis (hazard ratio [HR], 2.55 [95% CI, 2.46-2.64];
conclusionsModerate AS was associated with higher risk of death and lifetime loss compared with patients with no/mild AS.
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