Evidence map›Paper›PMID 38699999›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Associations of Relative Intensity of Physical Activity With Incident Cardiovascular Events and All-Cause Mortality.

Benjamin T Schumacher, Michael J LaMonte, Chongzhi Di, Humberto Parada, Steven P Hooker, John Bellettiere, Eleanor M Simonsick, Sandy Liles, Andrea Z LaCroix

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Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin T SchumacherHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-3099-3387
Michael J LaMonteDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York, USA.
Chongzhi DiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Humberto ParadaDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, California, USA.ORCID 0000-0001-6562-8577
Steven P HookerCollege of Health and Human Services, San Diego State University, San Diego, California, USA.
John BellettiereHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Eleanor M SimonsickTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.ORCID 0000-0002-5460-3494
Sandy LilesHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.

Funding

The Baltimore Longitudinal Study Of AgingZIAAG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI SIMONSICK, ELEANOR MARIE · 2009 to 2025
$116.9M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Research Education CoreU54CA132384 · NCI · SAN DIEGO STATE UNIVERSITY · PI CRIPPS, RICHARD MATTHEW, CROWE, SHEILA E. · 2008 to 2022
$20.7M
Research Education CoreU54CA132379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARREDONDO, ELVA M, CROWE, SHEILA E. · 2008 to 2021
$16.1M
San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tala Al-Rousan · 2018 to 2026
$7.4M
Objective Physical Activity and Cardiovascular Health in Older Women: OPACH2R01HL153462 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LACROIX, ANDREA Z., LAMONTE, MICHAEL J · 2022 to 2025
$6.2M
Objective Physical Activity and Cardiovascular Health in Women Aged 80 and OlderR01HL105065 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LACROIX, ANDREA Z. · 2011 to 2014
$5.0M
Statistical methods for analyzing objectively measured physical activity dataR01HL130483 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Chongzhi Di · 2016 to 2026
$4.4M
Red Blood Cell Polyunsaturated Fatty Acids and Breast Cancer Mortality in the Women's Healthy Eating and Living (WHEL) StudyK01CA234317 · NCI · SAN DIEGO STATE UNIVERSITY · PI PARADA, HUMBERTO · 2019 to 2023
$928k
NCATS NIH HHS UL1 TR001412NCI NIH HHS K01 CA234317NCI NIH HHS U54 CA132379NCI NIH HHS U54 CA132384NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL105065NHLBI NIH HHS R01HL105065NHLBI NIH HHS R01 HL130483NHLBI NIH HHS R01 HL153462NIA NIH HHS P30 AG059299NIH HHSNINR NIH HHS HHSN268201600018C
6 · The paper itself

Abstract

backgroundThe relative intensity of physical activity (PA) can be estimated as the percent of one's maximal effort required.

methodsWe compared associations of relative and absolute intensity PA with incident major cardiovascular disease (CVD) and all-cause mortality in 5 633 women from the Objective Physical Activity and Cardiovascular Health Study (mean age 78.5 ± 6.7). Absolute intensity was measured by accelerometry. Relative intensity was estimated by dividing accelerometer-estimated metabolic equivalents (METs) by maximal MET capacity. Both were aggregated into mean daily hours of light intensity PA (LPA) and moderate-to-vigorous PA (MVPA). Cox proportional hazard models estimated hazard ratios (HRs) for 1-hour higher amounts of PA on outcomes.

resultsDuring follow-up (median = 7.4 years), there were 748 incident CVD events and 1 312 deaths. Greater LPA and MVPA, on either scale, were associated with reduced risk of both outcomes. HRs for a 1-hour increment of absolute LPA were 0.88 (95% CI: 0.83-0.93) and 0.88 (95% CI: 0.84-0.92) for incident CVD and mortality, respectively. HRs for a 1-hour increment of absolute MPVA were 0.73 (95% CI: 0.61-0.87) and 0.55 (95% CI: 0.48-0.64) for the same outcomes. HRs for a 1-hour increment of relative LPA were 0.70 (95% CI: 0.59-0.84) and 0.78 (95% CI: 0.68-0.89) for incident CVD and mortality, respectively. HRs for a 1-hour increment of relative MPVA were 0.89 (95% CI: 0.83-0.96) and 0.82 (95% CI: 0.77-0.87) for the same outcomes. On the relative scale, LPA was more strongly, and inversely associated with both outcomes than relative MVPA. Absolute MVPA was more strongly inversely associated with the outcomes than relative MVPA.

conclusionsFindings support the continued shift in the PA intensity paradigm toward recommendation of more movement, regardless of intensity. Relative LPA--a modifiable, more easily achieved behavioral target, particularly among ambulatory older adults--was associated with reduced risk of incident major CVD and death.

Indexed as

AccelerometryCardiovascular DiseasesExerciseAgedAged, 80 and overCause of DeathFemaleHumansIncidenceProportional Hazards ModelsAccelerometryAgingEpidemiologyVO2max

Identifiers

PMID38699999
PMCPMC11212487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.