Evidence map›Paper›PMID 38699846›Full record

ArticleHistology and histopathology2024

Histopathological and statistical study of corneal repair in rabbits. A new way to understand corneal recovery.

Patricia Ramírez-Perdomo, Juan Daniel Hernández-Marrero, Santiago Guillén-Molina, Pedro Saavedra-Santana, Mónica de León-Vera, Eduardo José Araujo-Ruano, Juan Francisco Loro-Ferrer, Juan José Cabrera-Galván, Juan Andrés Ramírez-González

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Article in Histology and histopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patricia Ramírez-PerdomoMorphology Department, Las Palmas de Gran Canaria University (ULPGC), Gran Canaria, Spain.
Juan Daniel Hernández-MarreroExotics Animal´s Veterinary Service (Serviexotic), Gran Canaria, Spain.
Santiago Guillén-MolinaAlbion Ophthalmological Clinic, Gran Canaria, Spain.
Pedro Saavedra-SantanaMathematics Department, Las Palmas de Gran Canaria University (ULPGC), Gran Canaria, Spain.
Mónica de León-VeraVeterinary Specialities (OFTALVET), Gran Canaria, Spain.
Eduardo José Araujo-RuanoMorphology Department, Las Palmas de Gran Canaria University (ULPGC), Gran Canaria, Spain.
Juan Francisco Loro-FerrerClinical Sciences Department, Las Palmas de Gran Canaria University, Gran Canaria, Spain.
Juan José Cabrera-GalvánMorphology Department, Las Palmas de Gran Canaria University (ULPGC), Gran Canaria, Spain. juanjose.cabrera@ulpgc.es.
Juan Andrés Ramírez-GonzálezMorphology Department, Las Palmas de Gran Canaria University (ULPGC), Gran Canaria, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aims to evaluate corneal healing post amniotic membrane transplantation in controlled corneal defects, justifying its application in routine ophthalmology practice. The objective is to establish a reliable method for assessing the repair process. In three groups of six adult New Zealand rabbits, keratectomy and a monolayer transplant of dehydrated human amniotic membrane (AM) were conducted in the left eye (OS) with the right eye (OD) serving as the control eye. Clinical signs were assessed, and both eyes were enucleated at 1, 2, and 4 weeks for optical coherence tomography (OCT) measurements and histological analysis, collecting data from different epithelium, stroma, and limbus regions. This study was conducted using a formula that combines histologic data categorizing their presence and/or type as beneficial for corneal repair. No statistically significant differences were found between the experimental and control eyes regarding all clinical signs and OCT measurements. However, a linear model using histopathological results showed a period-implant mode interaction with statistical significance (

Indexed as

AmnionCorneaTomography, Optical CoherenceWound HealingAnimalsCorneal InjuriesDisease Models, AnimalHumansKeratectomyRabbits

Identifiers

PMID38699846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.