Evidence map›Paper›PMID 38699777›Full record

ArticleInnovation (Cambridge (Mass.))2024

Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells.

Alfred Akinlalu, Zachariah Flaten, Komila Rasuleva, Md Saimon Mia, Aaron Bauer, Santhalingam Elamurugan, Nega Ejjigu, Sudipa Maity, Amara Arshad, Min Wu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innovation (Cambridge (Mass.)), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alfred AkinlaluDepartment of Electrical and Computer Engineering, University of Denver, 2155 E Wesley Avenue, Denver, CO 80210, USA.
Zachariah FlatenBiomedical Engineering Program, North Dakota State University; 1401 Centennial Boulevard, Engineering Administration, Room 203, Fargo, ND 58102, USA.
Komila RasulevaBiomedical Engineering Program, North Dakota State University; 1401 Centennial Boulevard, Engineering Administration, Room 203, Fargo, ND 58102, USA.
Md Saimon MiaDepartment of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, 1001 S. 1401 Albrecht Boulevard Sudro Hall, Fargo, ND 58102, USA.
Aaron BauerBiomedical Engineering Program, North Dakota State University; 1401 Centennial Boulevard, Engineering Administration, Room 203, Fargo, ND 58102, USA.
Santhalingam ElamuruganBiomedical Engineering Program, North Dakota State University; 1401 Centennial Boulevard, Engineering Administration, Room 203, Fargo, ND 58102, USA.
Nega EjjiguBiomedical Engineering Program, North Dakota State University; 1401 Centennial Boulevard, Engineering Administration, Room 203, Fargo, ND 58102, USA.
Sudipa MaityCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Amara ArshadMaterials and Nanotechnology Program, North Dakota State University, 1410 North 14th Avenue, CIE 201, Fargo, ND 58102, USA.
Min WuWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China.
Wenjie XiaDepartment of Aerospace Engineering, Iowa State University, Ames, IA 50011, USA.
Jia FanCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Ang GuoDepartment of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, 1001 S. 1401 Albrecht Boulevard Sudro Hall, Fargo, ND 58102, USA.
Sijo MathewDepartment of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, 1001 S. 1401 Albrecht Boulevard Sudro Hall, Fargo, ND 58102, USA.
Dali SunDepartment of Electrical and Computer Engineering, University of Denver, 2155 E Wesley Avenue, Denver, CO 80210, USA.

Funding

Exosomal Contents Guided Amino Acids Treatment for Pancreatic CancerR21CA270748 · NCI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI SUN, DALI · 2022 to 2023
$369k
NCI NIH HHS R21 CA270748
6 · The paper itself

Abstract

Pancreatic adenocarcinoma (PDAC) is one of the most deadly cancers, characterized by extremely limited therapeutic options and a poor prognosis, as it is often diagnosed during late disease stages. Innovative and selective treatments are urgently needed, since current therapies have limited efficacy and significant side effects. Through proteomics analysis of extracellular vesicles, we discovered an imbalanced distribution of amino acids secreted by PDAC tumor cells. Our findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids, including isoleucine and histidine, via extracellular vesicles. These amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor cells. Both

Identifiers

PMID38699777
PMCPMC11063643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.