ArticleJournal of oral biology and craniofacial research
High-dose pulsed hyaluronidase for managing nasal skin necrosis following hyaluronic acid treatment in nasolabial folds: A case report.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Standardized Non-surgical Rhinoplasty with Hyaluronic Acid: Consistent Outcomes Across Injectors with Varying Experience.Aesthetic plastic surgery · 2026Article
- Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.Journal of clinical medicine · 2025Review
- A Randomized Clinical Trial Comparing Pure Hyaluronic Acid to the Hyaluronic Acid-Calcium Hydroxylapatite Combination for Temporal Volumization.Aesthetic surgery journal. Open forum · 2025Article
- Comparative in-vitro degradation of hyaluronic acids exposed to different hyaluronidase enzymes.Journal of oral biology and craniofacial researchArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing popularity of soft tissue filler injections has brought attention to the associated risks, particularly vascular complications, and their treatments. This case report focuses on a 34-year-old female who developed nasal skin necrosis following hyaluronic acid (HA) filler injection for nasolabial fold (NLF) enhancement. Despite the careful procedure, complications emerged rapidly, emphasizing the critical importance of prompt diagnosis and intervention. A total of 10,000 turbidity reducing units (TRU) of hyaluronidase (HSE) were administered in a high-dose pulsed manner, alongside hyperbaric oxygen therapy. The patient experienced a gradual but significant improvement over 60 days. This case underscores the need for constant vigilance in aesthetic medicine and the potential consequences of even minute HA amounts, exceeding zero, in causing severe vascular events.
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