Evidence map›Paper›PMID 38699484›Full record

ArticleClinical kidney journal2024

Maintained renin-angiotensin-aldosterone system inhibitor therapy with sodium zirconium cyclosilicate following a hyperkalaemia episode: a multicountry cohort study.

Anjay Rastogi, Charles V Pollack, Ignacio José Sánchez Lázaro, Eva Lesén, Matthew Arnold, Stefan Franzén, Alaster Allum, Ignacio Hernández, Toyoaki Murohara, Eiichiro Kanda

Abstract read
In one paragraph

Article in Clinical kidney journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
  5. Management of hypertension in chronic kidney disease.Clinical medicine (London, England) · 2026
    Review
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anjay RastogiDepartment of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Charles V PollackDepartment of Emergency Medicine, University of Mississippi School of Medicine, Jackson, MS, USA.
Ignacio José Sánchez LázaroCardiology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Eva LesénBioPharmaceuticals Medical CVRM Evidence, AstraZeneca, Gothenburg, Sweden.
Matthew ArnoldReal World Science and Digital, AstraZeneca, Cambridge, UK.
Stefan FranzénMedical & Payer Evidence Statistics, AstraZeneca, Gothenburg, Sweden.
Alaster AllumBioPharmaceuticals Medical CVRM, AstraZeneca, Cambridge, UK.
Ignacio HernándezAtrys Health, Madrid, Spain.
Toyoaki MuroharaDepartment of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Eiichiro KandaDepartment of Medical Science, Kawasaki Medical School, Okayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This observational cohort study compared the likelihood of maintained (stabilized/up-titrated) renin-angiotensin-aldosterone system inhibitor (RAASi) therapy at 6 months following hyperkalaemia in patients with chronic kidney disease (CKD) and/or heart failure (HF) from the USA, Japan and Spain who received sodium zirconium cyclosilicate (SZC) for at least 120 days, relative to those with no prescription for a potassium (K Methods: Using health registers and hospital medical records, patients with CKD and/or HF receiving RAASi therapy who experienced a hyperkalaemia episode were identified. Propensity score (PS) matching (1:4) was applied to balance the SZC cohort to the no K Results: The PS-matched SZC cohort included 565 (USA), 776 (Japan) and 56 (Spain) patients; the no K Conclusions: In routine clinical practice across three countries, patients treated with SZC were substantially more likely to maintain guideline-concordant RAASi therapy at 6 months following hyperkalaemia relative to patients with no K

Indexed as

chronic kidney diseaseheart failurehyperkalaemiarenin–angiotensin–aldosterone system inhibitorsodium zirconium cyclosilicate

Identifiers

PMID38699484
PMCPMC11062025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.