Evidence map›Paper›PMID 38699440›Full record

ArticleJBMR plus2024

Loss-of-function

Mizuho Kittaka, Noriyoshi Mizuno, Hiroyuki Morino, Tetsuya Yoshimoto, Tianli Zhu, Sheng Liu, Ziyi Wang, Kotoe Mayahara, Kyohei Iio, Kaori Kondo and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Cherubism: An African-Focused Review.Children (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Mizuho KittakaIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Noriyoshi MizunoDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Hiroyuki MorinoDepartment of Medical Genetics, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan.
Tetsuya YoshimotoIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Tianli ZhuDepartment of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN 46202, United States.
Sheng LiuIndiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Ziyi WangDepartment of Molecular Biology and Biochemistry, Okayama University Medical School, Okayama 700-8558, Japan.
Kotoe MayaharaDepartment of Orthodontics, Nihon University School of Dentistry, Tokyo 101-8310, Japan.
Kyohei IioDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Kaori KondoHematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo 113-8677, Japan.
Toshio KondoDepartment of Molecular Biology and Biochemistry, Okayama University Medical School, Okayama 700-8558, Japan.
Tatsuhide HayashiDepartment of Dental Materials Science, School of Dentistry, Aichi Gakuin University, Aichi 464-8650, Japan.
Sarah CoghlanIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Yayoi TenoIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Andrew Anh Phung DoanIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Marcus LevitanIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Roy B ChoiDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Shinji MatsudaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Kazuhisa OuharaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Jun WanIndiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Annelise M CassidyDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Stephane PelletierDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Sheela NampoothiriDepartment of Pediatric Genetics, Amrita Institute of Medical Sciences & Research Centre, Kerala 682041, India.
Andoni J UrtizbereaInstitut de Myologie, Paris 75013, France.
Alexander G RoblingDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Mitsuaki OnoDepartment of Molecular Biology and Biochemistry, Okayama University Medical School, Okayama 700-8558, Japan.
Hideshi KawakamiDepartment of Molecular Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
Ernst J ReichenbergerDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, CT 06030, United States.
Yasuyoshi UekiIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.

Funding

Mechanism of Bone Resorption in PeriodontitisR01DE025870 · NIDCR · UNIVERSITY OF MISSOURI KANSAS CITY · PI UEKI, YASUYOSHI · 2016 to 2020
$2.1M
Mechanisms of osteocyte induction and regulation of pathogen-induced osteolysisR01DE032036 · NIDCR · INDIANA UNIVERSITY INDIANAPOLIS · PI Yasuyoshi Ueki · 2023 to 2026
$1.7M
Characterization of OGFRL1 Knockout MiceR21DE030561 · NIDCR · INDIANA UNIVERSITY INDIANAPOLIS · PI UEKI, YASUYOSHI · 2021 to 2022
$436k
NIDCR NIH HHS R01 DE025870NIDCR NIH HHS R01 DE032036NIDCR NIH HHS R21 DE030561
6 · The paper itself

Abstract

Cherubism (OMIM 118400) is a rare craniofacial disorder in children characterized by destructive jawbone expansion due to the growth of inflammatory fibrous lesions. Our previous studies have shown that gain-of-function mutations in SH3 domain-binding protein 2 (SH3BP2) are responsible for cherubism and that a knock-in mouse model for cherubism recapitulates the features of cherubism, such as increased osteoclast formation and jawbone destruction. To date,

Indexed as

autosomal recessivecherubismloss of functionmouse modelmutationOGFRL1rare diseasewhole exome sequencing

Identifiers

PMID38699440
PMCPMC11062026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.