Evidence map›Paper›PMID 38699335›Full record

ArticleResearch square2024

Association analysis between an epigenetic risk score and blood pressure.

Helena Bui, Amena Keshawarz, Mengyao Wang, Mikyeong Lee, Scott M Ratliff, Lisha Lin, Kira S Birditt, Jessica D Faul, Annette Peters, Christian Gieger and 28 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors.

Helena BuiNational Heart Lung and Blood Institute.
Amena KeshawarzNational Heart Lung and Blood Institute.
Mengyao WangBoston University School of Public Health.
Mikyeong LeeNational Institute of Environmental Health Sciences.
Scott M RatliffUniversity of Michigan.
Lisha LinUniversity of Michigan.
Kira S BirdittUniversity of Michigan.
Jessica D FaulUniversity of Michigan.
Annette PetersHelmholtz Munich, German Research Center for Environmental Health.
Christian GiegerGerman Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance.
Thomas DelerueHelmholtz Munich, German Research Center for Environmental Health.
Sharon L R KardiaUniversity of Michigan.
Wei ZhaoUniversity of Michigan.
Xiuqing GuoLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center.
Jie YaoLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center.
Jerome I RotterLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center.
Yi LiBoston University School of Public Health.
Xue LiuBoston University School of Public Health.
Dan LiuGerman Center for Neurodegenerative Diseases.
Juliana F TavaresGerman Center for Neurodegenerative Diseases.
Gökhan PehlivanGerman Center for Neurodegenerative Diseases.
Monique M B BretelerGerman Center for Neurodegenerative Diseases.
Irma KarabegovicErasmus MC University Medical Center.
Carolina Ochoa-RosalesErasmus MC University Medical Center.
Trudy VoortmanErasmus MC University Medical Center.
Mohsen GhanbariErasmus MC University Medical Center.
Joyce B J van MeursErasmus MC University Medical Center.
Mohamed Kamal NasrUniversity Medicine Greifswald.
Marcus DörrGerman Center for Cardiovascular Research (DZHK), Partner Site Greifswald.
Hans J GrabeUniversity Medicine Greifswald.
Stephanie J LondonNational Institute of Environmental Health Sciences.
Alexander TeumerUniversity Medicine Greifswald.
Melanie WaldenbergerGerman Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance.
David R WeirUniversity of Michigan.
Jennifer A SmithUniversity of Michigan.
Daniel LevyNational Heart Lung and Blood Institute.
Jiantao MaTufts University.
Chunyu LiuCarolina Ochoa-Rosales.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Genomic Predictors of Arteriosclerosis in HypertensivesR01HL087660 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2007 to 2009
$5.1M
STUDIES OF OCCUPATIONAL CANCER--PESTICIDESZ01CP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALAVANJA, MICHAEL · 1996 to 2008
$5.0M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Intramural NIH HHS Z01 CP010119Intramural NIH HHS Z01 ES043012Intramural NIH HHS Z01 ES049030NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL133221NHLBI NIH HHS R01 HL141292NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS U10 HL054457NIAAA NIH HHS R01 AA028263NIA NIH HHS R01 AG060110NIA NIH HHS U01 AG009740NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

Background: Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. Results: We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. We found an association of alcohol intake with the ERS in the meta-analysis with 0.09 units higher ERS per drink consumed per day ( Conclusions: Our findings provide proof-of-concept that utilizing an ERS is a useful approach to capture the recent health consequences of lifestyle behaviors such as alcohol consumption.

Indexed as

alcoholblood pressureDNA methylationepigenetic risk scorehypertension

Identifiers

PMID38699335
PMCPMC11065078

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.