Evidence map›Paper›PMID 38699271›Full record

ArticleChemical science2024

Deconvoluting nitric oxide-protein interactions with spatially resolved multiplex imaging.

Yi Li, Kaijun Pan, Yanan Gao, Jia Li, Yi Zang, Xin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi LiCollege of Pharmaceutical Sciences, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University 866 Yuhangtang Street Hangzhou 310058 China lixin81@zju.edu.cn.ORCID https://orcid.org/0009-0001-3505-8080
Kaijun PanJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University Nanjing 210009 China.
Yanan GaoJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University Nanjing 210009 China.
Jia LiJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University Nanjing 210009 China.
Yi ZangLingang Laboratory Shanghai 201203 China yzang@lglab.ac.cn.
Xin LiCollege of Pharmaceutical Sciences, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University 866 Yuhangtang Street Hangzhou 310058 China lixin81@zju.edu.cn.ORCID https://orcid.org/0000-0001-5154-2115

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simultaneous imaging of nitric oxide (NO) and its proximal proteins should facilitate the deconvolution of NO-protein interactions. While immunostaining is a primary assay to localize proteins in non-genetically manipulated samples, NO imaging probes with immunostaining-compatible signals remain unexplored. Herein, probe NOP-1 was developed with an NO-triggered proximal protein labeling capacity and fluorogenic signals. The trick is to fuse the native chemical ligation of acyl benzotriazole with the protein-conjugation-induced fluorogenic response of Si-rhodamine fluorophore. NOP-1 predominantly existed in the non-fluorescent spirocyclic form. Yet, its acyl

Identifiers

PMID38699271
PMCPMC11062118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.