Evidence map›Paper›PMID 38699223›Full record

ArticleJournal of the American College of Emergency Physicians open2024

Rapid recognition and optimal management of hemophilia in the emergency department: A quality improvement project.

Asinamai M Ndai, Brandon R Allen, Tung T Wynn, Anita Rajasekhar, Ziad Saqr, Ina Sandeli, Scott M Vouri, Rachel Reise

Abstract read
In one paragraph

Article in Journal of the American College of Emergency Physicians open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Social vulnerability, access to care, and outcomes in hemophilia.Blood vessels, thrombosis & hemostasis · 2026
    Article
  2. [Chinese guidelines for emergency management of bleeding in hemophilia patients (2024)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Asinamai M NdaiDepartment of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USA.ORCID https://orcid.org/0000-0002-2517-3915
Brandon R AllenDepartment of Emergency Medicine University of Florida College of Medicine Gainesville Florida USA.
Tung T WynnDivision of Pediatric Hematology/Oncology Department of Pediatrics University of Florida College of Medicine Gainesville Florida USA.
Anita RajasekharDivision of Hematology/Oncology Department of Medicine University of Florida College of Medicine Gainesville Florida USA.
Ziad SaqrDepartment of Emergency Medicine University of Florida College of Medicine Gainesville Florida USA.
Ina SandeliDepartment of Emergency Medicine University of Florida College of Medicine Gainesville Florida USA.
Scott M VouriDepartment of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USA.
Rachel ReiseDepartment of Pharmaceutical Outcomes and Policy College of Pharmacy University of Florida Gainesville Florida USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to assess the effectiveness of a continuous quality improvement initiative at the University of Florida Health Physicians practice in reducing the time to administer factor replacement therapy (FRT) for hemophilia patients presenting with bleeding in the emergency department (ED). Methods: The study, a quasi-experimental, interventional design, was conducted between January 2020 and January 2023. The intervention, implemented in September 2021, involved training ED physicians, creating a specialized medication order set within the electronic health record (EHR), and a rapid triage system. The effectiveness was measured by comparing the time from ED arrival to factor administration before and after the intervention and benchmarking it against the National Bleeding Disorders Foundation's Medical and Scientific Advisory Council (MASAC)-recommended 1-hour timeline for factor administration. An interrupted time series (ITS) analysis with a generalized least squares model assessed the intervention's impact. Results: A total of 43 ED visits (22 pre-intervention and 21 post-intervention) were recorded. Post-intervention, the average time from ED arrival to factor administration decreased from 5.63 to 3.15 hours. There was no significant increase (27% vs. 29%) in the patients receiving factor within 1-hour of ED arrival. The ITS analysis predicted a 20-hour reduction in the average quarterly time to administer factor by the end of the study, an 84% decrease. Conclusions: The quality improvement program decreased the time to administer FRT for patients with hemophilia in the ED. However, the majority of patients did not achieve the 1-hour MASAC-recommended timeline for factor administration after ED arrival.

Indexed as

bleedingemergency departmentfactor replacement therapyhemophiliaquality improvement

Identifiers

PMID38699223
PMCPMC11065154

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.