Evidence map›Paper›PMID 38698981›Full record

ArticleHeliyon2024

Conditional reprogrammed human limbal epithelial cell model for anti-SARS-CoV-2 drug screening.

Yu Xiao, Ling Wang, Shi-Xu Li, Shi-Song Fang, Fan Luo, Shu-Liang Chen, Xuan Zou, Lin Ye, Wei Hou

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yu XiaoShenzhen Research Institute, Wuhan University, Shenzhen 518057, Guangdong Province, China.
Ling WangShenzhen Eye Hospital, Shenzhen 518040, Guangdong Province, China.
Shi-Xu LiShenzhen Eye Hospital, Shenzhen 518040, Guangdong Province, China.
Shi-Song FangShenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong Province, China.
Fan LuoState Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei Province, China.
Shu-Liang ChenState Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei Province, China.
Xuan ZouShenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong Province, China.
Lin YeShenzhen Eye Hospital, Shenzhen 518040, Guangdong Province, China.
Wei HouShenzhen Research Institute, Wuhan University, Shenzhen 518057, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To minimize the global pandemic COVID-19 spread, understanding the possible transmission routes of SARS-CoV-2 and discovery of novel antiviral drugs are necessary. We describe here that the virus can infect ocular surface limbal epithelial, but not other regions. Limbal supports wild type and mutant SARS-CoV-2 entry and replication depending on ACE2, TMPRSS2 and possibly other receptors, resulting in slight CPE and arising IL-6 secretion, which symbolizes conjunctivitis in clinical symptoms. With this limbal model, we have screened two natural product libraries and discovered several unreported drugs. Our data reveal important commonalities between COVID-19 and ocular infection with SARS-CoV-2, and establish an ideal cell model for drug screening and mechanism research.

Indexed as

Cell modelCOVID-19Drug screeningLimbal

Identifiers

PMID38698981
PMCPMC11064458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.