Evidence map›Paper›PMID 38698866›Full record

ArticleFrontiers in immunology2024

High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL-17 against

Paul Ogongo, Anthony Tran, Florence Marzan, David Gingrich, Melissa Krone, Francesca Aweeka, Cecilia S Lindestam Arlehamn, Jeffrey N Martin, Steven G Deeks, Peter W Hunt and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Multifaceted regulation of immune cells in radiation-induced pulmonary fibrosis: from mechanistic insights to targeted therapies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  4. Article
  5. Article
  6. bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Experimental dissection of tuberculosis protective immunity: a human perspective.Frontiers in cellular and infection microbiology · 2025
    Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Paul OgongoDivision of Experimental Medicine, University of California, San Francisco, San Francisco, CA, United States.
Anthony TranDivision of Experimental Medicine, University of California, San Francisco, San Francisco, CA, United States.
Florence MarzanDrug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, CA, United States.
David GingrichDrug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, CA, United States.
Melissa KroneDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
Francesca AweekaDrug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, CA, United States.
Cecilia S Lindestam ArlehamnCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Jeffrey N MartinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
Steven G DeeksDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, United States.
Peter W HuntDivision of Experimental Medicine, University of California, San Francisco, San Francisco, CA, United States.
Joel D ErnstDivision of Experimental Medicine, University of California, San Francisco, San Francisco, CA, United States.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Functionally distinct human CD4 T cell responses to novel evolutionarily selected M. tuberculosis antigensR01AI173002 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joel D. Ernst · 2023 to 2026
$3.4M
NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI173002
6 · The paper itself

Abstract

Background: Interleukin-17-producing CD4 T cells contribute to the control of Methods: We performed high-definition characterization of circulating Results: We identified two subsets of Th17 cells: subset 1 defined as CD4 Conclusions: We found differential effects of ART-suppressed HIV on distinct subsets of Th17 cells, that IL-17-producing CD4 T cells dominate responses to

Indexed as

Antigens, BacterialHIV InfectionsInterleukin-17Latent TuberculosisMycobacterium tuberculosisTh17 CellsAdultFemaleHumansImmunophenotypingKynurenineMaleMiddle AgedPhenotypeT-Lymphocyte SubsetsTryptophanAntigens, BacterialIL17A protein, humanInterleukin-17KynurenineTryptophanantigen-responsiveART-suppressedCD4 T-cellsHIVimmunityinterleukin-17kynurenine pathwaytuberculosis

Identifiers

PMID38698866
PMCPMC11064812

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.