Evidence map›Paper›PMID 38698845›Full record

ArticleFrontiers in immunology2024

Rapid generation of human recombinant monoclonal antibodies from antibody-secreting cells using ferrofluid-based technology.

Veronica Strazza, Marco Rossi, Andrea Avati, Giusy Tiseo, Marco Falcone, Maria Grazia Cusi, Francesco Menichetti, Paola Ricciardi-Castagnoli, Cristina Tinti, Piero Pileri

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Veronica StrazzaHyper Antibody Research & Development (HARD) -Lab, Toscana Life Sciences Foundation, Siena, Italy.
Marco RossiHyper Antibody Research & Development (HARD) -Lab, Toscana Life Sciences Foundation, Siena, Italy.
Andrea AvatiHyper Antibody Research & Development (HARD) -Lab, Toscana Life Sciences Foundation, Siena, Italy.
Giusy TiseoInfectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy.
Marco FalconeInfectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy.
Maria Grazia CusiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Francesco MenichettiInfectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy.
Paola Ricciardi-CastagnoliHyper Antibody Research & Development (HARD) -Lab, Toscana Life Sciences Foundation, Siena, Italy.
Cristina TintiHyper Antibody Research & Development (HARD) -Lab, Toscana Life Sciences Foundation, Siena, Italy.
Piero PileriHyper Antibody Research & Development (HARD) -Lab, Toscana Life Sciences Foundation, Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoclonal antibodies (mAbs) are one of the most important classes of biologics with high therapeutic and diagnostic value, but traditional methods for mAbs generation, such as hybridoma screening and phage display, have limitations, including low efficiency and loss of natural chain pairing. To overcome these challenges, novel single B cell antibody technologies have emerged, but they also have limitations such as

Indexed as

Antibodies, MonoclonalAntibody-Producing CellsCOVID-19Recombinant ProteinsSARS-CoV-2Antibodies, ViralFemaleHumansAntibodies, MonoclonalAntibodies, ViralRecombinant Proteinsantibody secreting cells (ASCs)antigen-specific ASCsCD138-ferrofluidCOVID-19functional selectionhuman monoclonal antibodiessingle cell PCRtranscriptionally active PCR (TAP)

Identifiers

PMID38698845
PMCPMC11064063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.