Evidence map›Paper›PMID 38698736›Full record

ArticleACR open rheumatology2024

A PD-1

Mehreen Elahee, Alisa A Mueller, Runci Wang, Kathryne E Marks, Takanori Sasaki, Ye Cao, Andrea Fava, Paul F Dellaripa, Francesco Boin, Deepak A Rao

Abstract read
In one paragraph

Article in ACR open rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mehreen ElaheeBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Alisa A MuellerBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Runci WangBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0001-9536-2845
Kathryne E MarksBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Takanori SasakiBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0001-9720-0698
Ye CaoBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Andrea FavaJohns Hopkins University School of Medicine, Baltimore, Maryland.ORCID https://orcid.org/0000-0001-6738-4836
Paul F DellaripaBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0003-0237-739X
Francesco BoinCedars-Sinai Medical Center, Los Angeles, California.ORCID https://orcid.org/0000-0003-4840-3063
Deepak A RaoBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0001-9672-7746

Funding

Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Molecular control of CD4 T cell ability to help B cellsK08AR072791 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAO, DEEPAK ANGARA · 2018 to 2022
$764k
Burroughs Wellcome FundDoris Duke Charitable FoundationNIAMS NIH HHS AR070253NIAMS NIH HHS AR072791NIAMS NIH HHS K08 AR072791NIAMS NIH HHS P30 AR070253Rheumatology Research FoundationU.S. Department of Defense SL200016P1
6 · The paper itself

Abstract

objectiveT cells contribute to tissue injury in systemic sclerosis (SSc), yet the specific T cell subsets expanded in patients with SSc remain incompletely defined. Here we evaluated specific phenotypes and functions of peripheral helper T (Tph) and follicular helper T (Tfh) cells, which have been implicated in autoantibody production, and assessed their associations with clinical features in a well-characterized cohort of patients with SSc.

methodsMass cytometry of T cells from peripheral blood mononuclear cells of patients with SSc and controls were evaluated using t-distributed stochastic neighbor embedding visualization, biaxial gating, and marker expression levels. Findings were validated with flow cytometry and in vitro assays.

resultsThe frequencies of PD-1

conclusionAmong PD-1

Identifiers

PMID38698736
PMCPMC11246828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.