ArticleBrain and behavior2024
Detecting language network alterations in mild cognitive impairment using task-based fMRI and resting-state fMRI: A comparative study.
Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Altered dynamic functional connectivity of the language network associated with electronegative L5 in patients with mild cognitive impairment.GeroScience · 2026Article
- Whole-Brain Static Functional Connectivity Disruptions Based on the Default Mode Network in Patients with Mild Cognitive Impairment.Brain topography · 2026Article
- Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Active Video Games to Improve Behavioral Intentions and Cognitive Function in Patients With Schizophrenia: Randomized Controlled Trial.JMIR serious games · 2025Article
- Altered angular gyrus activation during the digit symbol substitution test in people living with HIV: beyond information processing speed deficits.Scientific reports · 2025Article
- Research progress in predicting the conversion from mild cognitive impairment to Alzheimer's disease via multimodal MRI and artificial intelligence.Frontiers in neurology · 2025Review
- Detecting language network alterations in mild cognitive impairment using task-based fMRI and resting-state fMRI: A comparative study.Brain and behavior · 2024Article
- Iron deposition is associated with motor and non-motor network breakdown in parkinsonism.Frontiers in aging neuroscience · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe objective of this study was to investigate the functional changes associated with mild cognitive impairment (MCI) using independent component analysis (ICA) with the word generation task functional magnetic resonance imaging (fMRI) and resting-state fMRI.
methodsIn this study 17 patients with MCI and age and education-matched 17 healthy individuals as control group are investigated. All participants underwent resting-state fMRI and task-based fMRI while performing the word generation task. ICA was used to identify the appropriate independent components (ICs) and their associated networks. The Dice Coefficient method was used to determine the relevance of the ICs to the networks of interest.
resultsIC-14 was found relevant to language network in both resting-state and task-based fMRI, IC-4 to visual, and IC-28 to dorsal attention network (DAN) in word generation task-based fMRI by Sorento-Dice Coefficient. ICA showed increased activation in language network, which had a larger voxel size in resting-state functional MRI than word generation task-based fMRI in the bilateral lingual gyrus. Right temporo-occipital fusiform cortex, right hippocampus, and right thalamus were also activated in the task-based fMRI. Decreased activation was found in DAN and visual network MCI patients in word generation task-based fMRI.
conclusionTask-based fMRI and ICA are more sophisticated and reliable tools in evaluation cognitive impairments in language processing. Our findings support the neural mechanisms of the cognitive impairments in MCI.
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