Evidence map›Paper›PMID 38698549›Full record

ArticleJournal of the American Chemical Society2024

Bioluminescence Imaging of Potassium Ion Using a Sensory Luciferin and an Engineered Luciferase.

Shengyu Zhao, Ying Xiong, Ranganayakulu Sunnapu, Yiyu Zhang, Xiaodong Tian, Hui-Wang Ai

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Shengyu ZhaoDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Ying XiongDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Ranganayakulu SunnapuDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Yiyu ZhangDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0001-8636-2827
Xiaodong TianDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0001-9590-9943
Hui-Wang AiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0002-5664-3270

Funding

Next-Gen Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound ProcessingR01EB033172 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai, Thanos Tzounopoulos · 2022 to 2026
$3.3M
An Integrated Fluorescent Biosensor, Imaging, and Analysis Toolkit for Islet BiologicsR01DK122253 · NIDDK · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2020 to 2023
$1.6M
Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's DiseaseRF1AG077773 · NIA · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2022 to 2022
$1.6M
Next-Generation ATP-Independent Luciferases, Luciferins, and Bioluminescent Calcium IndicatorsR01EB035430 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai · 2024 to 2026
$1.4M
NIA NIH HHS RF1 AG077773NIBIB NIH HHS R01 EB033172NIBIB NIH HHS R01 EB035430NIDDK NIH HHS R01 DK122253
6 · The paper itself

Abstract

Bioluminescent indicators are power tools for studying dynamic biological processes. In this study, we present the generation of novel bioluminescent indicators by modifying the luciferin molecule with an analyte-binding moiety. Specifically, we have successfully developed the first bioluminescent indicator for potassium ions (K

Indexed as

LuciferasesLuminescent MeasurementsPotassiumAnimalsFirefly LuciferinHumansLuminescent AgentsMiceProtein EngineeringFirefly LuciferinLuciferasesLuminescent AgentsPotassium

Identifiers

PMID38698549
PMCPMC11100015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.