Evidence map›Paper›PMID 38698454›Full record

ArticlePilot and feasibility studies2024

Lifestyle management and brain MRI metrics in female Australian adults living with multiple sclerosis: a feasibility and acceptability study.

Olivia Wills, Brooklyn Wright, Lisa-Marie Greenwood, Nadia Solowij, Mark Schira, Jerome J Maller, Alok Gupta, John Magnussen, Yasmine Probst

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Olivia WillsSchool of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia. ow873@uowmail.edu.au.ORCID http://orcid.org/0000-0001-8155-6286
Brooklyn WrightSchool of Psychology, University of Wollongong, Wollongong, NSW, 2522, Australia.
Lisa-Marie GreenwoodIllawara Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.
Nadia SolowijSchool of Psychology, University of Wollongong, Wollongong, NSW, 2522, Australia.
Mark SchiraSchool of Psychology, University of Wollongong, Wollongong, NSW, 2522, Australia.
Jerome J MallerGeneral Electric Healthcare, Richmond, Melbourne, Australia.
Alok GuptaIllawara Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.
John MagnussenFaculty of Medicine, Health and Human Sciences, Macquarie University, Macquarie Park, NSW, 2109, Australia.
Yasmine ProbstSchool of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited studies of multiple sclerosis (MS) exist whereby magnetic resonance imaging (MRI) of the brain with consistent imaging protocols occurs at the same time points as collection of healthy lifestyle measures. The aim of this study was to test the feasibility, acceptability and preliminary efficacy of acquiring MRI data as an objective, diagnostic and prognostic marker of MS, at the same time point as brain-healthy lifestyle measures including diet.

methodsParticipants living with relapsing remitting MS partook in one structural MRI scanning session of the brain, completed two online 24-hour dietary recalls and demographic and self-reported lifestyle questionnaires (e.g. self-reported disability, comorbidities, physical activity, smoking status, body mass index (BMI), stress). Measures of central tenancy and level of dispersion were calculated for feasibility and acceptability of the research protocols. Lesion count was determined by one radiologist and volumetric analyses by a data analysis pipeline based on FreeSurfer software suite. Correlations between white matter lesion count, whole brain volume analyses and lifestyle measures were assessed using Spearman's rank-order correlation coefficient.

resultsThirteen female participants were included in the study: eligibility rate 90.6% (29/32), recruitment rate 46.9% (15/32) and compliance rate 87% (13/15). The mean time to complete all required tasks, including MRI acquisition was 115.86 minutes

conclusionsAcquiring MRI brain scans at the same time point as lifestyle profiles in adults with MS is both feasible and accepted among adult females living with MS. Quantification of volumetric MRI data support further investigations using semi-automated pipelines among people living with MS, with pre-processing steps identified to increase automated feasibility. This protocol may be used to determine relationships between elements of a brain-healthy lifestyle, including dietary intake, and measures of disease burden and brain health, as assessed by T1-weighted and T2-weighted lesion count and whole brain volume, in an adequately powered sample.

trial registrationThe study protocol was retrospectively registered in the Australia New Zealand Clinical Trials Registry (ACTRN12624000296538).

Indexed as

DietDisabilityLifestyleMagnetic resonance imaging (MRI)Multiple sclerosis (MS)

Identifiers

PMID38698454
PMCPMC11064336

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.