Evidence map›Paper›PMID 38698250›Full record

ArticleIrish journal of medical science2024

Short-term, nonsurgical periodontal therapy boosts interleukin-12 levels and reduces oral cancer risk.

Hazza A Alhobeira, Anamika Sharma, Ananya Sharma, Mahvish Khan, Mohtashim Lohani, Saif Khan, Eslam K Fahmy, Safya E Esmaeel, Anshoo Agarwal

Abstract read
PubMed Publisher
In one paragraph

Article in Irish journal of medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hazza A AlhobeiraDepartment of Restorative Dentistry, College of Dentistry, University of Ha'il, Ha'il 55473, Saudi Arabia.
Anamika SharmaDepartment of Dentistry, LLRM Medical College, CCS University Meerut, Meerut, 250002, UP, India. profanamika091@gmail.com.ORCID http://orcid.org/0009-0001-7537-4627
Ananya SharmaDepartment of Dentistry, LLRM Medical College, CCS University Meerut, Meerut, 250002, UP, India.
Mahvish KhanDepartment of Biology, College of Science, University of Ha'il, Ha'il 55473, Saudi Arabia.
Mohtashim LohaniMedical Research Centre, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Saif KhanDepartment of Basic Dental and Medical Sciences, College of Dentistry, University of Ha'il, Ha'il 55473, Saudi Arabia.
Eslam K FahmyPhysiology Department, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Safya E EsmaeelPhysiology Department, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Anshoo AgarwalPathology Department, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.

Funding

Deanship of Scientific Research, University of Ha'il 1404-BA
6 · The paper itself

Abstract

backgroundCytokines, including interleukin-12 (IL-12), are proteins that regulate cell survival, proliferation, differentiation, and function. IL-12 is a heterodimeric proinflammatory cytokine. It possesses tumoricidal properties and promotes M1 macrophage polarization and IFN-γ production by T helper (Th1) cells, which in turn stimulates the antitumor cytotoxic cluster of eight positive (CD8+) and natural killer cells, therefore activating an effector immune response against tumor cells. MATERIALS AND

methodsHerein, the IL-2 levels of 60 patients with generalized chronic periodontitis (GCP) were assessed. Plaque index, gingival index, pocket probing depth, bleeding on probing percentage (BOP %), and clinical attachment loss were the clinical indicators reported.

resultsPatients with GCP in the pretreatment group had substantially lower mean IL-12 levels than those in the post-treatment group. Short-term, nonsurgical treatment (NST) considerably improved periodontal indices and increased IL-12 levels, thereby reducing oral cancer risk.

conclusionNST is a cost-effective and accessible cancer prevention procedure for general dentists.

Indexed as

Chronic PeriodontitisInterleukin-12Mouth NeoplasmsAdultFemaleHumansMaleMiddle AgedPeriodontal IndexInterleukin-12Chronic periodontitisInterleukin-12Oral cancerShort-term nonsurgical treatment

Identifiers

PMID38698250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.