ArticleScientific reports2024
Association between biological aging and periodontitis using NHANES 2009-2014 and mendelian randomization.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Bioinformatics analysis reveals shared gene signatures and molecular mechanisms between periodontitis and rheumatoid arthritis in the context of aging.Acta odontologica Scandinavica · 2026Article
- Epigenetic Age Acceleration, Neurocognition and Oral Health in Nigerian Adolescents With and Without HIV.The Pediatric infectious disease journal · 2026Article
- Association between periodontal and geriatric health: a cross-sectional study.Clinical oral investigations · 2026Article
- Circadian disruption and cellular senescence: emerging perspectives in periodontitis.Odontology · 2026Review
- A cross-sectional study of supragingival microbiome depending on age in Korean population.Scientific reports · 2026Article
- Association between dietary fiber intake and mortality in populations with accelerated biological aging: a study based on NHANES 1999-2018 data.Journal of clinical biochemistry and nutrition · 2026Article
- Body fat percentage and hypertension risk: A population-based observational and Mendelian randomization study.Medicine · 2026Observational
- The Mediating Role of Biological Age Advance in the Association Between Periodontitis and Mortality: Biological Aging Links Periodontitis to Mortality.Clinical and experimental dental research · 2026Article
- Is There Evidence Supporting the use of Dermatoglyphics as an Auxiliary Diagnostic Method for Periodontitis? A Scoping Review.International journal of dentistry · 2026Review
- Oral Hygiene Status, Tooth Loss, and Periodontal Disease Severity in Mexican Adults: A Cross-Sectional Study.International journal of dentistry · 2026Article
- Harnessing generative artificial intelligence for periodontitis prediction: a machine learning approach integrating systemic health indicators for precision oral health in resource-limited settings.Frontiers in dental medicine · 2026Article
- Aging and coronary artery calcification: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Unraveling the causal association of epigenetic age acceleration with common oral diseases and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis.Clinical epigenetics · 2025Article
- Burden and forecast of severe periodontitis in BRICS-Plus nations: trends from 1990 to 2040.International journal for equity in health · 2025Article
- Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis.Diabetes research and clinical practice · 2025Article
- Association between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data.Clinical oral investigations · 2025Article
- From mitochondria to immune networks: new mesenchymal stem cell strategies to treat periodontitis.Stem cell research & therapy · 2025Review
- Article
- ANXA2 regulates mitochondrial function and cellular senescence of PDLCs via AKT/eNOS signaling pathway under high glucose conditions.Scientific reports · 2025Article
- Microbiome composition and metabolic pathways in shallow and deep periodontal pockets.Scientific reports · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Aging is a recognized risk factor for periodontitis, while biological aging could provide more accurate insights into an individual's functional status. This study aimed to investigate the potential association between biological aging and periodontitis. Epidemiological data from 9803 participants in the 2009-2014 National Health and Nutrition Examination Survey were analyzed at a cross-sectional level to assess this link. Three biological ages [Klemera-Doubal method (KDM), PhenoAge, and homeostatic dysregulation (HD)] and two measures of accelerated biological aging (BioAgeAccel and PhenoAgeAccel) were set as primary exposure and were calculated. Logistic regression and restricted cubic spline regression were employed to examine the relationship between biological aging and periodontitis. Additionally, Mendelian randomization analysis was conducted to explore the causal connection between accelerated biological aging and periodontitis. After adjusting for age, gender, race, educational level, marital status, ratio of family income, and disease conditions, this study, found a significant association between subjects with older higher biological ages, accelerated biological aging, and periodontitis. Specifically, for a per year increase in the three biological ages (HD, KDM, and PhenoAge), the risk of periodontitis increases by 15%, 3%, and 4% respectively. Individuals who had positive BioAgeAccel or PhenoAgeAccel were 20% or 37% more likely to develop periodontitis compared with those who had negative BioAgeAccel or PhenoAgeAccel. Furthermore, a significant non-linear positive relationship was observed between the three biological ages, accelerated biological aging, and periodontitis. However, the Mendelian randomization analysis indicated no causal effect of accelerated biological aging on periodontitis. Our findings suggest that biological aging may contribute to the risk of periodontitis, highlighting the potential utility of preventive strategies targeting aging-related pathways in reducing periodontitis risk among older adults.
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