ArticleScientific reports2024
Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Review
- Homocysteine levels and cancer risk in hypertensive adults across MTHFR C677T genotypes.Scientific reports · 2026Article
- Nanozyme-SERS dual-function sensor based on capillaries for the detection of Hcy in the serum of CRC patients.Analytical and bioanalytical chemistry · 2026Article
- Development of multi-algorithm machine learning models integrating novel serum biomarkers for survival prediction in colorectal cancer: a retrospective cohort study.Frontiers in oncology · 2026Article
- Clinical characteristics and risk factors in patients with colon cancer liver metastases.Frontiers in oncology · 2026Article
- Colorectal Cancer: Pathogenesis and Targeted Therapy.MedComm · 2025Review
- Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression.International journal of molecular sciences · 2025Review
- Development of a chemiluminescent immunoassay based on magnetic solid phase for quantification of homocysteine in human serum.BMC biotechnology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This study aimed to evaluate the significance of homocysteine (HCY) levels in predicting recurrence-free survival (RFS) and overall survival (OS) in colorectal cancer (CRC) patients. This retrospective study involved 1272 CRC patients. The risk of mortality increased with increasing HCY levels in CRC patients. The optimal HCY cutoff value in CRC patients was 15.2 μmol/L. The RFS (45.8% vs. 60.5%, p < 0.001) and OS (48.2% vs. 63.2%, p < 0.001) of patients with high HCY levels were significantly lower than those of patients with low HCY levels. Patients with high HCY levels were older, male, had large tumours, high carcinoembryonic antigen (CEA) levels, and long hospital stays, and incurred high hospitalisation costs. Multivariate analysis showed that when HCY levels exceeded 15.2 μmol/L, the risk of adverse RFS and OS increased by 55.7% and 61.4%, respectively. Subgroup analysis showed that HCY levels could supplement CEA levels and pathological staging. We constructed HCY-based prognostic nomograms, which demonstrated feasible discrimination and calibration values better than the traditional tumour, node, metastasis staging system for predicting RFS and OS. Elevated serum HCY levels were strongly associated with poor RFS and OS in CRC patients. HCY-based prognostic models are effective tools for a comprehensive evaluation of prognosis.
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Registered trials
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