ArticleNature communications2024
Dinuclear gold-catalyzed divergent dechlorinative radical borylation of gem-dichloroalkanes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Counterion-enabled divergent reactivity in dinuclear gold photoredox catalysis.Nature communications · 2026Article
- (Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications.Angewandte Chemie (International ed. in English) · 2026Review
- Cobaloxime Catalysis: A General Platform for Mizoroki-Heck-Type Reactions and Catalytic Dehydrohalogenations of Unactivated Alkyl Chlorides.Journal of the American Chemical Society · 2026Article
- Copper-CatalyzedThe Journal of organic chemistry · 2026Article
- Tetrachloromethane as an editable all-carbon quaternary source.Nature communications · 2026Article
- Bidentate mixed-ligand strategy in dinuclear gold photoredox catalysis.Nature communications · 2025Article
- Activation ofThe Journal of organic chemistry · 2025Article
- Catalytic Reductive Homocoupling of Benzyl Chlorides Enabled by Zirconocene and Photoredox Catalysis.Precision chemistry · 2025Article
- Diversity-oriented synthesis of stereodefined tetrasubstituted alkenes via a modular alkyne gem-addition strategy.Nature communications · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enormous and widespread use of organoboronic acids has prompted the development of innovative synthetic methodologies to meet the demands on structural diversity and functional group tolerance. The existing photoinduced defunctionalization radical borylation, typically focused on the conversion of one C-X bond (X= Br, I, or other leaving group) into only one C-B bond. Herein, we disclose a divergent radical dechloroborylation reaction enabled by dinuclear gold catalysis with visible light irradiation. A wide range of structurally diverse alkyl boronic, α-chloroboronic, and gem-diboronic esters can be synthesized in moderate to good yields (up to 92%). Its synthetic robustness is further demonstrated on a preparative scale and applied to late-stage diversification of complex molecules. The process hinges on a C-Cl bond relay activation in readily available gem-dichloroalkanes through inner-sphere electron transfer, overcoming the redox potential limits of unreactive alkyl chlorides.
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Registered trials
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