Evidence map›Paper›PMID 38698055›Full record

ArticleScientific reports2024

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation.

Yusuf O Cakmak, Prashanna Khwaounjoo, Joseph Pangilinan, Innes K Wise, Chris Burrows, Pranish Kolakshyapati, Zoe Williams, Paul Bannon

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yusuf O CakmakPoint-of-Care Technologies Theme, Centre for Bioengineering and Nanotechnology, Dunedin, New Zealand. Yusuf.cakmak@otago.ac.nz.
Prashanna KhwaounjooCakmak Lab, Department of Anatomy, School of Biomedical Sciences, University of Otago, PO BOX 56, Dunedin, 9054, New Zealand.
Joseph PangilinanCakmak Lab, Department of Anatomy, School of Biomedical Sciences, University of Otago, PO BOX 56, Dunedin, 9054, New Zealand.
Innes K WiseHybrid Theatre, Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Chris BurrowsHybrid Theatre, Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Pranish KolakshyapatiHybrid Theatre, Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Zoe WilliamsHybrid Theatre, Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Paul BannonHybrid Theatre, Charles Perkins Centre, The University of Sydney, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive neuromodulation of non-compressible internal organs has significant potential for internal organ bleeding and blood-shift in aero/space medicine. The present study aims to investigate the potential influences of the non-invasive transcutaneous electrical nerve stimulation (TENS) on multiple non-compressible internal organs' blood flow. Porcine animal model (n = 8) was randomized for a total of 48 neuromodulation sessions with two different TENS stimulation frequencies (80 Hz, 10 Hz) and a placebo stimulation. A combination of two different electrode configurations (Abdominal-only or Abdominal and hind limb) were also performed. Intraarterial blood flow measurements were taken during pre and post-stimulation periods at the left renal artery, common hepatic artery, and left coronary artery. Intracranial, and extracranial arterial blood flows were also assessed with digital subtraction angiography. TENS with abdominal-only electrode configurations at 10 Hz demonstrated significant reductions in average peak blood flow velocity (APV) of the common hepatic artery (p = 0.0233) and renal arteries (p = 0.0493). Arterial pressures (p = 0.0221) were also significantly lower when renal APV was reduced. The outcome of the present study emphasises the potential use of TENS in decreasing the blood flow of non-compressible internal organs when the correct combination of electrodes configuration and frequency is used.

Indexed as

Transcutaneous Electric Nerve StimulationAbdomenAnimalsBlood Flow VelocityHepatic ArteryRegional Blood FlowRenal ArterySwineBlood flowBlood-shiftNeuromodulationNon-compressibleNon-invasiveTENS

Identifiers

PMID38698055
PMCPMC11066058

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.