ArticleScientific reports2024
Genome plasticity shapes the ecology and evolution of Phocaeicola dorei and Phocaeicola vulgatus.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
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- Integrated metabolomic and gut microbiota analyses reveal TCA cycle dysfunction in broiler skeletal disorders and the protective effect of L‑malic acid.Journal of animal science and biotechnology · 2026Article
- Targeting the gut-ovarian axis:mSystems · 2026Article
- Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages.Viruses · 2026Review
- Characterization of the Oral and Stomach Microbial Community Structure in Patients with Intestinal Metaplasia, Dysplasia, and Gastric Cancer Through High-Throughput Sequencing.Microorganisms · 2026Article
- Gut dysbiosis in a murine model of cutaneous lupus erythematosus correlates with antigen-specific T cells and antigen-presenting cells in skin.Scientific reports · 2026Article
- Gut microbiota variation in admixed Hispanic populations with polyendocrine metabolic ovarian syndrome.Frontiers in endocrinology · 2026Article
- Integrative analysis across metagenomic taxonomic classifiers: A case study of the gut microbiome in aging and longevity in the Integrative Longevity Omics Study.PLoS computational biology · 2026Article
- Multi-omics characterization of a rhizosphere-derivedFrontiers in microbiology · 2026Article
- Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients.PloS one · 2026Article
- The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features.Gut microbes · 2025Article
- Article
- The association between gut microbiota composition and cardiometabolic parameters in healthy adults.BMC microbiology · 2025Article
- Effects of cRG-I Prebiotic Treatment on Gut Microbiota Composition and Metabolic Activity in Dogs In Vitro.Microorganisms · 2025Article
- Gut microbiota profiles of peninsular Malaysian populations are associated with urbanization and lifestyle.Scientific reports · 2025Article
- Potential Modulatory Roles of Gut Microbiota and Metabolites in the Associations of Macronutrient-to-Physical Activity Ratios With Dyslipidemia.Journal of the American Heart Association · 2025Article
- Assessing the safety of microbiome perturbations.Microbial genomics · 2025Review
- Function-based selection of synthetic communities enables mechanistic microbiome studies.The ISME journal · 2025Article
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Authors and funding
5 authors.
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Abstract
Phocaeicola dorei and Phocaeicola vulgatus are very common and abundant members of the human gut microbiome and play an important role in the infant gut microbiome. These species are closely related and often confused for one another; yet, their genome comparison, interspecific diversity, and evolutionary relationships have not been studied in detail so far. Here, we perform phylogenetic analysis and comparative genomic analyses of these two Phocaeicola species. We report that P. dorei has a larger genome yet a smaller pan-genome than P. vulgatus. We found that this is likely because P. vulgatus is more plastic than P. dorei, with a larger repertoire of genetic mobile elements and fewer anti-phage defense systems. We also found that P. dorei directly descends from a clade of P. vulgatus¸ and experienced genome expansion through genetic drift and horizontal gene transfer. Overall, P. dorei and P. vulgatus have very different functional and carbohydrate utilisation profiles, hinting at different ecological strategies, yet they present similar antimicrobial resistance profiles.
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