Evidence map›Paper›PMID 38697943›Full record

ArticlePhysiological reports2024

Subthalamic nucleus synchronization between beta band local field potential and single-unit activity in Parkinson's disease.

Eric Bayman, Keanu Chee, Madelyn Mendlen, Daniel J Denman, Rex N Tien, Steven Ojemann, Daniel R Kramer, John A Thompson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eric BaymanDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0009-0002-0674-6789
Keanu CheeDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Madelyn MendlenDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Daniel J DenmanDepartment of Neurophysiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Rex N TienDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Steven OjemannDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Daniel R KramerDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
John A ThompsonDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Local field potential (LFP) oscillations in the beta band (13-30 Hz) in the subthalamic nucleus (STN) of Parkinson's disease patients have been implicated in disease severity and treatment response. The relationship between single-neuron activity in the STN and regional beta power changes remains unclear. We used spike-triggered average (STA) to assess beta synchronization in STN. Beta power and STA magnitude at the beta frequency range were compared in three conditions: STN versus other subcortical structures, dorsal versus ventral STN, and high versus low beta power STN recordings. Magnitude of STA-LFP was greater within the STN compared to extra-STN structures along the trajectory path, despite no difference in percentage of the total power. Within the STN, there was a higher percent beta power in dorsal compared to ventral STN but no difference in STA-LFP magnitude. Further refining the comparison to high versus low beta peak power recordings inside the STN to evaluate if single-unit activity synchronized more strongly with beta band activity in areas of high beta power resulted in a significantly higher STA magnitude for areas of high beta power. Overall, these results suggest that STN single units strongly synchronize to beta activity, particularly units in areas of high beta power.

Indexed as

Beta RhythmParkinson DiseaseSubthalamic NucleusAction PotentialsAgedDeep Brain StimulationFemaleHumansMaleMiddle AgedNeurons

Identifiers

PMID38697943
PMCPMC11065686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.