Evidence map›Paper›PMID 38697675›Full record

Observational studyBMJ open respiratory research2024

Single and multiple breath nitrogen washout compared with the methacholine test in patients with suspected asthma and normal spirometry.

Aline Stalder Siebeneichler, Desiree M Schumann, Meropi Karakioulaki, Nora Brachsler, Andrei M Darie, Leticia Grize, Thiago G Heck, Michael Tamm, Philipp Latzin, Daiana Stolz

Abstract readObservational StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aline Stalder SiebeneichlerClinic of Pneumology, University Hospital Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-3726-7481
Desiree M SchumannClinic of Pneumology, University Hospital Basel, Basel, Switzerland.
Meropi KarakioulakiClinic of Pneumology, University Hospital Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1067-8582
Nora BrachslerClinic of Pneumology, University Hospital Basel, Basel, Switzerland.
Andrei M DarieClinic of Pneumology, University Hospital Basel, Basel, Switzerland.
Leticia GrizeClinic of Pneumology, University Hospital Basel, Basel, Switzerland.
Thiago G HeckUNIJUI, Ijui, RS, Brazil.
Michael TammClinic of Pneumology, University Hospital Basel, Basel, Switzerland.
Philipp LatzinInselspital, Kinderklinik, University of Bern, Bern, Switzerland.
Daiana StolzClinic of Pneumology, University Hospital Basel, Basel, Switzerland daiana.stolz@uniklinik-freiburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMethods used to assess ventilation heterogeneity through inert gas washout have been standardised and showed high sensitivity in diagnosing many respiratory diseases. We hypothesised that nitrogen single or multiple breath washout tests, respectively nitrogen single breath washout (N STUDY DESIGN AND

methodsThis prospective, observational, single-centre study included patients with suspicion of asthma with normal spirometry. Patients completed questionnaires on symptoms and health-related quality-of-life and underwent the following lung function tests: N

results182 patients were screened and 106 were included in the study, with mean age of 41.8±14 years. The majority were never-smokers (58%) and women (61%). MCT was abnormal in 48% of participants, N

conclusionsBoth MCT and N

Indexed as

AsthmaBreath TestsBronchial Provocation TestsMethacholine ChlorideNitrogenSpirometryAdultBronchoconstrictor AgentsFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedProspective StudiesRespiratory Function TestsBronchoconstrictor AgentsMethacholine ChlorideNitrogenAsthmaAsthma MechanismsExhaled Airway MarkersRespiratory Measurement

Identifiers

PMID38697675
PMCPMC11086282

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.