Evidence map›Paper›PMID 38697479›Full record

Trial reportKidney international2024

Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV.

Annegret Pelchen-Matthews, Amanda Mocroft, Lene Ryom, Michael J Ross, Shweta Sharma, Steven Coca, Amit Achhra, Elaine Cornell, Russell Tracy, Andrew Phillips and 6 more

Erratum issuedAbstract readRandomized Controlled TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Kidney international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Annegret Pelchen-MatthewsCentre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, University College London, London, UK.
Amanda MocroftCentre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, University College London, London, UK; CHIP, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lene RyomCHIP, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Infectious Diseases 144, Hvidovre University Hospital, Copenhagen, Denmark.
Michael J RossDepartment of Medicine, Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA.
Shweta SharmaDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Steven CocaDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Amit AchhraDepartment of Medicine, Division of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut, USA.
Elaine CornellDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Russell TracyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Andrew PhillipsCentre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, University College London, London, UK.
Marta Montero AlonsoInfectious Diseases Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Giota ToulomiDepartment of Hygiene, Epidemiology & Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Brian K AganInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
Nicholas MedlandKirby Institute, University of New South Wales, Sydney, Australia.
Christina M WyattDepartment of Medicine, Division of Nephrology, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA. Electronic address: christina.wyatt@duke.edu.
INSIGHT START Study Group

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)UM1AI068641 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2011 to 2014
$83.5M
International Network for Strategic Initiatives in Global HIV Trials (INSIGHT): STARTUM1AI120197 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2015 to 2017
$65.1M
Extended follow-up of randomized participants in the INSIGHT START trialU01AI136780 · NIAID · UNIVERSITY OF MINNESOTA · PI GRUND, BIRGIT, REILLY, CAVAN S. · 2019 to 2024
$18.0M
Impact of early antiretroviral therapy on kidney disease outcomesR01DK112258 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WYATT, CHRISTINA M · 2017 to 2021
$2.1M
Medical Research CouncilNCATS NIH HHS UL1 TR001863NIAID NIH HHS U01 AI136780NIAID NIH HHS UM1 AI068641NIAID NIH HHS UM1 AI120197NIDDK NIH HHS R01 DK112258
6 · The paper itself

Abstract

People with human immunodeficiency virus (HIV) are at risk for chronic kidney disease (CKD) due to HIV and antiretroviral therapy (ART) nephrotoxicity. Immediate ART initiation reduces mortality and is now the standard of care, but the long-term impact of prolonged ART exposure on CKD is unknown. To evaluate this, the Strategic Timing of Antiretroviral Treatment (START) trial randomized 4,684 ART-naïve adults with CD4 cell count under 500 cells/mm

Indexed as

Glomerular Filtration RateHIV InfectionsRenal Insufficiency, ChronicAdultAlbuminuriaAnti-HIV AgentsApolipoprotein L1CD4 Lymphocyte CountCreatinineDrug Administration ScheduleFemaleHumansIncidenceKidneyMaleMiddle AgedAnti-HIV AgentsApolipoprotein L1CreatininealbuminuriaAPOL1chronic kidney diseaseglomerular filtration ratenephrotoxicity

Identifiers

PMID38697479
PMCPMC11193627

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.