Evidence map›Paper›PMID 38696376›Full record

ArticlePLOS global public health2024

Exploring HIV risk perception mechanisms among youth in a test-and-treat trial in Kenya and Uganda.

Lawrence Owino, Jason Johnson-Peretz, Joi Lee, Monica Getahun, Dana Coppock-Pector, Irene Maeri, Anjeline Onyango, Craig R Cohen, Elizabeth A Bukusi, Jane Kabami and 6 more

Abstract read
In one paragraph

Article in PLOS global public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lawrence OwinoKenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Jason Johnson-PeretzDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, California, United States of America.ORCID https://orcid.org/0000-0001-9561-6366
Joi LeeDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, California, United States of America.
Monica GetahunDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, California, United States of America.ORCID https://orcid.org/0000-0002-2116-2637
Dana Coppock-PectorDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, California, United States of America.
Irene MaeriKenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Anjeline OnyangoKenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Craig R CohenDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, California, United States of America.ORCID https://orcid.org/0000-0001-8654-6634
Elizabeth A BukusiKenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Jane KabamiInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
James AyiekoKenya Medical Research Institute (KEMRI), Nairobi, Kenya.ORCID https://orcid.org/0000-0002-0324-4006
Maya PetersenDivisions of Biostatistics and Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California, United States of America.ORCID https://orcid.org/0000-0002-5505-153X
Moses R KamyaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.ORCID https://orcid.org/0000-0001-9106-4234
Edwin CharleboisCenter for AIDS Prevention Studies, University of California, San Francisco, San Francisco, California, United States of America.
Diane HavlirHIV, Infectious Disease and Global Medicine, University of California, San Francisco, San Francisco, California, United States of America.
Carol S CamlinDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, California, United States of America.

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Optimizing Adherence to PrEP among Young African Women through a Community Adherence Club InterventionK23MH114760 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOSS, CATHERINE ANNE STIMETS · 2018 to 2021
$796k
NIAID NIH HHS UM1 AI068636NIMH NIH HHS K23 MH114760NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

Understanding risk perception and risk-taking among youth can inform targeted prevention efforts. Using a health beliefs model-informed framework, we analysed 8 semi-structured, gender-specific focus group discussions with 93 youth 15-24 years old (48% male, 52% female), drawn from the SEARCH trial in rural Kenya and Uganda in 2017-2018, coinciding with the widespread introduction of PrEP. Highly connected social networks and widespread uptake of antiretrovirals shaped youth HIV risk perception. Amid conflicting information about HIV prevention methods, youth felt exposed to multiple HIV risk factors like the high prevalence of HIV, belief that people with HIV(PWH) purposefully infect others, dislike of condoms, and doubts about PrEP efficacy. Young women also reported minimal sexual autonomy in the context of economic disadvantages, the ubiquity of intergenerational and transactional sex, and peer pressure from other women to have many boyfriends. Young men likewise reported vulnerability to intergenerational sex, but also adopted a sexual conquest mentality. Comprehensive sexuality education and economic empowerment, through credible and trusted sources, may moderate risk-taking. Messaging should leverage youth's social networks to spread fact-based, gender- and age-appropriate information. PrEP should be offered alongside other reproductive health services to address both pregnancy concerns and reduce HIV risk.

Identifiers

PMID38696376
PMCPMC11065277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.