Evidence map›Paper›PMID 38696270›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

Monocyte Production of C1q Potentiates CD8

Taylor Eddens, Olivia B Parks, Dequan Lou, Li Fan, Jorna Sojati, Manda Jo Ramsey, Lori Schmitt, Claudia M Salgado, Miguel Reyes-Mugica, Alysa Evans and 5 more

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026
    Review
  2. Article
  3. Article
  4. Monocytes: See One Queuing Local Adaptive Immune Responses to Respiratory Viruses.American journal of respiratory cell and molecular biology · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Taylor EddensDivision of Allergy/Immunology, Department of Pediatrics.
Olivia B ParksDivision of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Dequan LouDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Li FanDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Jorna SojatiDivision of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Manda Jo RamseyDivision of Blood and Marrow Transplant and Cellular Therapies, Department of Pediatrics.
Lori SchmittDepartment of Pathology.
Claudia M SalgadoDepartment of Pathology.
Miguel Reyes-MugicaDepartment of Pathology.ORCID 0000-0001-5698-3702
Alysa EvansProgram in Microbiology and Immunology, and.
Henry M ZouDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Tim D OuryDepartment of Pathology.
Craig ByersdorferDivision of Blood and Marrow Transplant and Cellular Therapies, Department of Pediatrics.
Kong ChenDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
John V WilliamsDivision of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
TRAINING PROGRAM FOR MD/PHD STUDENTST32GM008208 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINMAN, RICHARD A · 1987 to 2021
$15.4M
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Host Determinants of Human Metapneumovirus Immunity and PathogenesisR01AI085062 · NIAID · VANDERBILT UNIVERSITY · PI John V. Williams · 2010 to 2026
$5.6M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Epigenetic regulation of chemokines in lung inflammationR01HL137709 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$1.6M
University of Pittsburgh Training Program in Antimicrobial ResistanceT32AI138954 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2019 to 2023
$971k
Age-dependent differences in the immune response to human metapneumovirusF30HL159915 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PARKS, OLIVIA · 2022 to 2025
$203k
Eunice Kennedy Shriver National Institute of Child Health and Human Development K12HD000850Henry L. Hillman FoundationNational Institute of Allergy and Infectious Diseases AI085062NHLBI NIH HHS 1F30HL159915NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS F30 HL159915NHLBI NIH HHS R01 HL137709NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI085062NIAID NIH HHS T32 AI138954NICHD NIH HHS K12 HD000850NIDA NIH HHS 75N95020D00005NIGMS NIH HHS T32 GM008208NIGMS NIH HHS T32GM008208ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Respiratory viral infections remain a leading cause of morbidity and mortality. Using a murine model of human metapneumovirus, we identified recruitment of a C1q-expressing inflammatory monocyte population concomitant with viral clearance by adaptive immune cells. Genetic ablation of C1q led to reduced CD8

Indexed as

CD8-Positive T-LymphocytesMonocytesAnimalsComplement C1qCOVID-19HumansInterferon-gammaLymphocyte ActivationMetapneumovirusMiceMice, Inbred C57BLParamyxoviridae InfectionsRespiratory Tract InfectionsSARS-CoV-2Complement C1qInterferon-gammaantiviral immunitycomplementCOVID-19human metapneumovirus

Identifiers

PMID38696270
PMCPMC11376238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.