ArticleJournal of cancer research and clinical oncology2024
Primary lung cancer in children and adolescents.
Article in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 3 citations in OpenAlex.
- Trajectories of pulmonary subsolid nodules in children and adolescents: a retrospective multicenter cohort study.European radiology · 2026Article
- Clinical and pathological analysis of pediatric patients with primary pulmonary tumors at a single center.Biomedical reports · 2026Article
- Natural history and clinical characteristics of pulmonary subsolid nodules in pediatric patients: a cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Pediatric lung ground glass nodules: a real-world, large-scale CT cohort analysis.BMC medical imaging · 2026Article
- Lightweight hybrid foundation model for lung cancer prognosis based on low-dose chest X-ray images.Translational lung cancer research · 2026Article
- Twelve-Year Follow-Up of a Pure Ground-Glass Opacity Initially Detected at 14 Years of Age and Treated by Extended Segmentectomy: A Case Report.Surgical case reports · 2026Article
- Age-related differences in clinical characteristics and survival in lung cancer.Frontiers in oncology · 2026Article
- Targeted therapies in lung cancer: personalizing treatment across the age spectrum.Frontiers in oncology · 2026Review
- Case Report: Synchronous ALK-positive laryngeal inflammatory myofibroblastic tumor and EGFR-mutant lung adenocarcinoma in a child.Frontiers in pediatrics · 2026Article
- Persistent burden and health inequalities of lung cancer among adolescents and young adults, 1990-2021.Frontiers in oncology · 2025Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
purposePrimary lung cancer is extremely rare in children and adolescents. The aim of this study is to clarify clinical features and outcomes of primary lung cancer in children and adolescents.
methodsYoung patients (aged ≤ 20 years) diagnosed as primary lung cancer between 2012 and 2023 were retrospective reviewed. According to radiological appearance of the nodules, they were divided into solid nodule (SN) group and ground glass opacity (GGO) group.
resultsA total of 74 patients were identified, with a median age at diagnosis of 18 years old (range: 11-20), including 7 patients in SN group and 67 patients in GGO group. In the GGO group, none of the nodules enlarged or changed during an average surveillance period of 10.8 months before surgery, except one. Wedge resection was the most common procedure (82.1%), followed by segmentectomy (16.4%) and lobectomy (1.5%). Histopathological analysis revealed that 64.2% of GGO nodules were adenocarcinoma in situ and minimally invasive adenocarcinomas, while the remaining 35.8% were invasive adenocarcinomas. Mutational analysis was performed in nine patients, with mutations identified in all cases. After a mean follow-up period of 1.73 ± 1.62 years, two patients in the SN group died due to multiple distant metastases, while all patients in the GGO group survived without recurrence. The overall survival (100%) of the GGO group was significantly higher than SN group (66.7%).
conclusionsPrimary lung cancer in children and adolescents are rare and histopathological heterogeneous. Persistent GGO nodules may indicate early-stage lung adenocarcinoma in children and adolescents.
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