Article in The Journal of experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
Yuexiao Tang *Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0009-0009-4719-5099
Tao Yao *Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0000-0002-5481-6019
Xin TianZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0009-0000-3074-0657
Xintong XiaKey Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province , Hangzhou, China.ORCID 0009-0002-4140-5728
Xingxiao HuangZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0009-0006-4560-1477
Zhewen QinZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0009-0006-7285-4971
Zhong ShenDepartment of Coloproctology, Hangzhou Third People's Hospital, Hangzhou, China.ORCID 0000-0002-2884-7743
Lin ZhaoZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0009-0001-3856-0084
Yaping ZhaoDivision of Life Sciences and Medicine, Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, China.ORCID 0009-0006-5017-342X
Bowen DiaoZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0009-0006-8556-3583
Yan PingZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0009-0006-4263-6930
Xiaoxiao ZhengKey Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province , Hangzhou, China.ORCID 0000-0002-0276-7518
Yonghao XuZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0009-0000-0540-0490
Hui ChenZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0000-0003-4413-1304
Tao QianDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0009-0005-6716-4776
Tao MaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0009-0006-0990-8172
Ben ZhouCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.ORCID 0000-0001-7177-2882
Suowen XuDivision of Life Sciences and Medicine, Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, China.ORCID 0000-0002-5488-5217
Qimin ZhouDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-9480-4872
Yong LiuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Frontier Science Center for Immunology and Metabolism, The Institute for Advanced Studies, Wuhan University , Wuhan, China.ORCID 0000-0001-7771-4181
Mengle ShaoCAS Key Laboratory of Molecular Virology and Immunology, The Center for Microbes, Development, and Health, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences , Shanghai, China.ORCID 0000-0002-5488-9904
Wei ChenKey Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province , Hangzhou, China.ORCID 0000-0002-1919-594X
Bo ShanZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University , Hangzhou, China.ORCID 0000-0002-1675-5809
Ying WuKey Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province , Hangzhou, China.ORCID 0009-0008-1808-3349
First Affiliated Hospital Zhejiang University · CNZhejiang Chinese Medical University · CNHangzhou First People's Hospital · CNShanghai Institute of Nutrition and Health · CNTongde Hospital of Zhejiang Province · CNUniversity of Science and Technology of China · CNShanghai Jiao Tong University · CNThird People's Hospital of Hangzhou · CNWuhan University · CNZhejiang Cancer Hospital · CN
Funding
Fundamental Research Funds for the Central Universities 226-2023-00061Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang 2022R01002National Key Research and Development Program of China 2022YFA1104102National Natural Science Foundation of China 32371235Natural Science Funding of Zhejiang Province LQ23H160003Shanghai Municipal Science and Technology 22140903200State Administration of Traditional Chinese Medicine GZY-ZJ-SY-2402Zhejiang Provincial Department of Science and Technology YSZX2401Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents
6 · The paper itself
Abstract
Platinum-based chemotherapy drugs can lead to the development of anorexia, a detrimental effect on the overall health of cancer patients. However, managing chemotherapy-induced anorexia and subsequent weight loss remains challenging due to limited effective therapeutic strategies. Growth differentiation factor 15 (GDF15) has recently gained significant attention in the context of chemotherapy-induced anorexia. Here, we report that hepatic GDF15 plays a crucial role in regulating body weight in response to chemo drugs cisplatin and doxorubicin. Cisplatin and doxorubicin treatments induce hepatic Gdf15 expression and elevate circulating GDF15 levels, leading to hunger suppression and subsequent weight loss. Mechanistically, selective activation by chemotherapy of hepatic IRE1α-XBP1 pathway of the unfolded protein response (UPR) upregulates Gdf15 expression. Genetic and pharmacological inactivation of IRE1α is sufficient to ameliorate chemotherapy-induced anorexia and body weight loss. These results identify hepatic IRE1α as a molecular driver of GDF15-mediated anorexia and suggest that blocking IRE1α RNase activity offers a therapeutic strategy to alleviate the adverse anorexia effects in chemotherapy.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy. · full record | OpenQuestion