Evidence map›Paper›PMID 38695862›Full record

ArticleeLife2024

Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function.

Rita De Gasperi, Laszlo Csernoch, Beatrix Dienes, Monika Gonczi, Jayanta K Chakrabarty, Shahar Goeta, Abdurrahman Aslan, Carlos A Toro, David Karasik, Lewis M Brown and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Rita De GasperiDepartment of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID https://orcid.org/0000-0002-5281-4263
Laszlo CsernochDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.ORCID https://orcid.org/0000-0002-2446-1456
Beatrix DienesDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Monika GoncziDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Jayanta K ChakrabartyQuantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, United States.
Shahar GoetaQuantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, United States.
Abdurrahman AslanSpinal Cord Damage Research Center, James J. Peters VA Medical Center, Bronx, United States.ORCID https://orcid.org/0000-0002-6730-4768
Carlos A ToroSpinal Cord Damage Research Center, James J. Peters VA Medical Center, Bronx, United States.ORCID https://orcid.org/0000-0002-7355-7534
David KarasikAzrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.ORCID https://orcid.org/0000-0002-8826-0530
Lewis M BrownQuantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, United States.
Marco BrottoBone-Muscle Research Center, College of Nursing & Health Innovation,University of Texas at Arlington, Austin, United States.
Christopher P CardozoSpinal Cord Damage Research Center, James J. Peters VA Medical Center, Bronx, United States.ORCID https://orcid.org/0000-0003-4013-2537
Columbia University · USJames J. Peters VA Medical Center · USUniversity of Debrecen · HUAllen Institute for Brain Science · USBar-Ilan University · ILThe University of Texas at Arlington · US

Funding

Transgenic and Mechanical Loading CoreP01AG039355 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI BONEWALD, LYNDA F · 2012 to 2024
$19.3M
Loss of Numb in Muscle Dysfunction in AgingR01AG060341 · NIA · BRONX VETERANS MEDICAL RESEARCH FDN · PI BROTTO, MARCO, CARDOZO, CHRISTOPHER P · 2018 to 2022
$2.4M
National Center on Medical Consequences of Spinal Cord InjuryI50RX002020 · VA · JAMES J PETERS VA MEDICAL CENTER · PI BAUMAN, WILLIAM A, SPUNGEN, ANN MICHELE · 2016 to 2020
–
NIA NIH HHS P01 AG039355NIA NIH HHS R01 AG060341NIA NIH HHS R-1AG060341RRD VA I50 RX002020
6 · The paper itself

Abstract

Here, we investigated the mechanisms by which aging-related reductions of the levels of

Indexed as

Intracellular Signaling Peptides and ProteinsMembrane ProteinsMice, KnockoutMuscle ContractionNerve Tissue ProteinsSarcomeresSeptinsAnimalsMiceMuscle Fibers, SkeletalProtein BindingIntracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsNumbl protein, mouseNumb protein, mouseSept7 protein, mouseSeptinscell biologycytoskeletonexcitation–contraction couplingmouseNumbsarcomere structureSeptinskeletal muscle

Identifiers

PMID38695862
PMCPMC11065422
OpenAlexW4386632047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.