Evidence map›Paper›PMID 38695853›Full record

ArticleAngewandte Chemie (International ed. in English)2024

Total Synthesis of Lissodendoric Acid A.

Francesca M Ippoliti, Laura G Wonilowicz, Nathan J Adamson, Evan R Darzi, Joyann S Donaldson, Daniel J Nasrallah, Milauni M Mehta, Andrew V Kelleghan, K N Houk, Neil K Garg

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesca M IppolitiDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-4655-0545
Laura G WonilowiczDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8503-6835
Nathan J AdamsonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-0872-0593
Evan R DarziDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-6900-2229
Joyann S DonaldsonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Daniel J NasrallahDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8010-6953
Milauni M MehtaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Andrew V KelleghanDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Neil K GargDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-7793-2629

Funding

Exploiting Unconventional Building Blocks in Chemical SynthesisR35GM139593 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Neil K. Garg · 2021 to 2026
$4.0M
NMR Console and Prodigy CryoProbeS10OD028644 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K · 2021 to 2021
$600k
Time-of-Flight Mass Spectrometer for Synthesis Supporting Biomedical ResearchS10RR025631 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUK, KENDALL N · 2009 to 2009
$328k
Harnessing Strained Intermediates to Access Complex MoleculesR01GM123299 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K · 2018 to 2018
$269k
Total Synthesis of Alstilobanine A Using a Strained Cyclic AlleneF32GM139289 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMSON, NATHAN JOSEPH · 2020 to 2022
$162k
Methodology towards the synthesis of complex stereochemically dense natural productsF32GM122245 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DARZI, EVAN RASHIED · 2017 to 2019
$160k
Division of Chemistry CHE-1048804Division of Chemistry CHE-2153972National Science Foundation OCI-1053575National Science Foundation Graduate Research Fellowship Program DGE-1650604National Science Foundation Graduate Research Fellowship Program DGE-2034835NCRR NIH HHS S10 RR025631NCRR NIH HHS S10RR025631NIGMS NIH HHS F32 GM122245NIGMS NIH HHS F32 GM139289NIGMS NIH HHS R01 GM123299NIGMS NIH HHS R35 GM139593NIH HHS S10 OD028644NIH HHS S10OD028644
6 · The paper itself

Abstract

We describe a full account of our synthetic strategy leading to the first total synthesis of the manzamine alkaloid lissodendoric acid A . These efforts demonstrate that strained cyclic allenes are valuable synthetic building blocks and can be employed efficiently in total synthesis.

Indexed as

AlkaloidsMolecular StructureStereoisomerismAlkaloidsasymmetric synthesisbioactive natural productcyclic allenescycloadditionstotal synthesis

Identifiers

PMID38695853
PMCPMC11461081

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.