Evidence map›Paper›PMID 38695350›Full record

ArticleeLife2024

The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact.

Marco van den Noort, Panagiotis Drougkas, Cristina Paulino, Bert Poolman

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 3 countries.

Marco van den NoortDepartment of Biochemistry, Groningen Biomolecular Science and Biotechnology Institute, University of Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0002-2025-461X
Panagiotis DrougkasDepartment of Biochemistry, Groningen Biomolecular Science and Biotechnology Institute, University of Groningen, Groningen, Netherlands.
Cristina PaulinoDepartment of Biochemistry, Groningen Biomolecular Science and Biotechnology Institute, University of Groningen, Groningen, Netherlands.
Bert PoolmanDepartment of Biochemistry, Groningen Biomolecular Science and Biotechnology Institute, University of Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0002-1455-531X
Biotechnology Institute · US

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 40.018.016Nederlandse Organisatie voor Wetenschappelijk Onderzoek 722.017.001Nederlandse Organisatie voor Wetenschappelijk Onderzoek Gravitation Program BaSyCNederlandse Organisatie voor Wetenschappelijk Onderzoek OCENW.KLEIN.526
6 · The paper itself

Abstract

Bacteria utilize various strategies to prevent internal dehydration during hypertonic stress. A common approach to countering the effects of the stress is to import compatible solutes such as glycine betaine, leading to simultaneous passive water fluxes following the osmotic gradient. OpuA from

Indexed as

ATP-Binding Cassette TransportersBacterial ProteinsLactococcus lactisAdenosine TriphosphatasesBetaineCryoelectron MicroscopyFluorescence Resonance Energy TransferOsmolar ConcentrationOsmoregulationProtein BindingProtein DomainsSingle Molecule ImagingAdenosine TriphosphatasesATP-Binding Cassette TransportersBacterial ProteinsBetaineBusAA protein, Lactococcus lactisOpuA protein, Lactococcus lactisABC importerinterdomain dynamicsmolecular biophysicsosmoregulatory transportersingle-molecule FRETsingle-particle cryo-EMstructural biologytransient protein-protein interactons

Identifiers

PMID38695350
PMCPMC11065425
OpenAlexW4389728459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.