SynthesisHuman vaccines & immunotherapeutics2024
Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis.
Synthesis in Human vaccines & immunotherapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Immunogenicity and safety of co-purified diphtheria, tetanus and acellular pertussis vaccine in 6-year-old Chinese children.Nature communications · 2025Trial
- Epidemiological characteristics and vaccination history analysis of pertussis in Quzhou from 2005 to 2024.Journal of health, population, and nutrition · 2026Article
- Clinical epidemiological characteristics and risk factors for severe pertussis in children in Xiamen.BMC infectious diseases · 2026Article
- Pertussis epidemiology and seroprevalence in Wujin District, Changzhou, China, 2024.BMC infectious diseases · 2026Article
- Pertussis epidemiological surveillance and immunization history in children under five years in a megacity in China from 2019 to 2023.Human vaccines & immunotherapeutics · 2025Article
- Resurgence of pertussis: Epidemiological trends, contributing factors, challenges, and recommendations for vaccination and surveillance.Human vaccines & immunotherapeutics · 2025Review
- Retrospective analysis of 104 cases of pediatric severe pertussis in Southern China.BMC infectious diseases · 2025Article
- Rising pertussis cases and deaths in China: current trends and clinical solutions.Emerging microbes & infections · 2024Article
- Article
- Epidemiology of Pertussis and the Screening Value of WBC and Lymphocyte Percentage.International journal of general medicine · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pertussis is a vaccine-preventable infectious disease; however, data on pertussis antibody levels in a nationwide population are still limited in China. We aimed to pool the seropositivity rates of IgG antibodies against pertussis toxin (PT-IgG) across the country. We systematically searched PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure Database for studies published between January 1, 2010, and June 30, 2023. Studies reporting the seroprevalence of PT-IgG among a healthy Chinese population were included. Pooled estimates were obtained using random-effects meta-analyzes. The meta-analysis included 39 studies (47,778 participants) reporting anti-PT IgG seropositivity rates. The pooled rate for all ages was 7.06% (95% CI, 5.50%-9.07%). Subgroup analyzes showed rates ranging from 6.36% to 12.50% across different age groups. This meta-analysis indicated a low anti-PT IgG seropositivity rate in the Chinese population, particularly among school-aged children and young adults. This finding underscores the urgent need to refine immunization strategies.
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Registered trials
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