Evidence map›Paper›PMID 38695100›Full record

ArticleJournal of the International AIDS Society2024

Impact of simplified HCV diagnostic strategies on the HCV epidemic among men who have sex with men in the era of HIV oral pre-exposure prophylaxis in Taiwan: a modelling study.

Huei-Jiuan Wu, Sophy TingFang Shih, Tanya L Applegate, Jisoo A Kwon, Evan B Cunningham, Jason Grebely, Richard T Gray

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International AIDS Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Reinfection and Resistance Associated Substitutions Following a Minimal Monitoring Approach for Hepatitis C Virus Treatment in MINMON Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Huei-Jiuan WuThe Kirby Institute, UNSW, Sydney, New South Wales, Australia.ORCID 0000-0002-5085-1976
Sophy TingFang ShihThe Kirby Institute, UNSW, Sydney, New South Wales, Australia.
Tanya L ApplegateThe Kirby Institute, UNSW, Sydney, New South Wales, Australia.
Jisoo A KwonThe Kirby Institute, UNSW, Sydney, New South Wales, Australia.
Evan B CunninghamThe Kirby Institute, UNSW, Sydney, New South Wales, Australia.
Jason GrebelyThe Kirby Institute, UNSW, Sydney, New South Wales, Australia.
Richard T GrayThe Kirby Institute, UNSW, Sydney, New South Wales, Australia.ORCID 0000-0002-2885-0483
UNSW Sydney · AU

Funding

National Health and Medical Research Council Investigator Grant 1176131UNSW Scientia Scholarship
6 · The paper itself

Abstract

introductionSimplified hepatitis C virus (HCV) diagnostic strategies have the potential to improve HCV diagnoses and treatment. We aimed to investigate the impact of simplified HCV diagnostic strategies on HCV incidence and its effect on HCV diagnosis and treatment among men who have sex with men (MSM) regardless of HIV status and use of HIV pre-exposure prophylaxis (PrEP) in Taiwan.

methodsA compartmental deterministic model was developed to describe the natural history of HCV disease progression, the HCV care cascade and the HIV status and PrEP using among MSM. The model was calibrated to available data for HCV and HIV epidemiology and population demographics in Taiwan. We simulated the epidemic from 2004 and projected the impact of simplified testing strategies on the HCV epidemic among MSM over 2022-2030.

resultsUnder the current testing approach in Taiwan, total HCV incidence would increase to 12.6 per 1000 person-years among MSM by 2030. Single-visit point-of-care RNA testing had the largest impact on reducing the number of new HCV infections over 2022-2030, with a 31.1% reduction (interquartile range: 24.9%-32.8%). By 2030, single-visit point-of-care HCV testing improved HCV diagnosis to 90.9%, HCV treatment to 87.7% and HCV cure to 81.5% among MSM living with HCV. Compared to status quo, prioritized simplified HCV testing for PrEP users and MSM living with diagnosed HIV had considerable impact on the broader HCV epidemic among MSM. A sensitivity analysis suggests that reinfection risk would have a large impact on the effectiveness of each point-of-care testing scenario.

conclusionsSimplified HCV diagnostic strategies could control the ongoing HCV epidemic and improve HCV testing and treatment among Taiwanese MSM. Single-visit point-of-care RNA testing would result in large reductions in HCV incidence and prevalence among MSM. Efficient risk-reduction strategies will need to be implemented alongside point-of-care testing to achieve HCV elimination among MSM in Taiwan.

Indexed as

Hepatitis CHIV InfectionsHomosexuality, MalePre-Exposure ProphylaxisAdultEpidemicsHumansIncidenceMaleMiddle AgedTaiwanYoung Adultclinic‐based reflex RNA testingdried blood spot testinghepatitis CHIV pre‐exposure prophylaxispoint‐of‐care RNA testingpoint‐of‐care testing

Identifiers

PMID38695100
PMCPMC11063777
OpenAlexW4396585654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.