ArticleAmerican journal of physiology. Renal physiology2024
Kidney collecting duct-derived vasopressin is not essential for appropriate concentration or dilution of urine.
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Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Endogenous vasopressin and vasopressin receptor 2 in bladder as anti-diuretic / anti-spasmodic targets for the treatment of multifactorial nocturia.Continence (Amsterdam, Netherlands) · 2025Article
- InducibleAmerican journal of physiology. Renal physiology · 2025Article
- The biology of water homeostasis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
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Authors and funding
11 authors at 4 institutions in 1 country.
Yvonne ZuchowskiDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-5253-7366
Joshua S CartyDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Jonathan B TrapaniVanderbilt University School of Medicine, Nashville, Tennessee, United States.ORCID 0000-0003-2479-9833
Jason A WattsEpigenetics and Stem Cell Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States.ORCID 0000-0001-6584-6961
Fabian BockDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-0788-2945
Mingzhi ZhangDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Andrew S TerkerDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-1498-9043
Roy ZentDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-2983-8133
Eric DelpireDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-3702-1599
Raymond C HarrisDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Juan Pablo ArroyoDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-5992-5011
Vanderbilt University Medical Center · USVanderbilt University · USNational Institutes of Health · USVA Tennessee Valley Healthcare System · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MWNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1MThe Role of the EGF Receptor in Acute and Chronic Renal InjuryR01DK051265 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 1997 to 2026
$10.1MThe Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5MThe role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulationR01DK062794 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2003 to 2026
$9.4Mcis-regulation of RNA polymerase pausing ZIAES103361 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WATTS, JASON · 2021 to 2025
$9.3MThe Role of renal macrophages in recovery from renal injuryR01DK095785 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2013 to 2026
$6.7MVanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C. · 2017 to 2021
$5.9MVANDERBILT NEPHROLOGY TRAINING PROGRAMT32DK007569 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C., IKIZLER, TALAT ALP · 1988 to 2024
$5.8MMedical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8MPrune Belly Syndrome: Mechanisms of Filamin A MutationsR01DK127589 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BAKER, LINDA A., QIN, JUN · 2020 to 2024
$2.5MInnovative therapeutic approaches to treat chronic kidney diseaseDP5OD033412 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TERKER, ANDREW S. · 2022 to 2025
$2.2MASN Foundation for Kidney Research (ASN Foundation) ASN-Kidney Cure career development awardASN Foundation for Kidney Research (ASN Foundation) Ben J. Lipps fellowshipBLRD VA I01 BX002196HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5R38HL167237HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK069921HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK127589HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K08DK134879HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K08 DK135931-01HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) RO1DK093501HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) NIEHS ES103361-01HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK51265HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK62794HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK7569HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK95785HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) P30DK114809HHS | NIH | OSC | Common Fund (NIH Common Fund) DP5OD033412NHLBI NIH HHS R38 HL167237NIDDK NIH HHS K08 DK134879NIDDK NIH HHS K08 DK135931NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK051265NIDDK NIH HHS R01 DK062794NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK095785NIDDK NIH HHS R01 DK127589NIDDK NIH HHS T32 DK007569NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIH HHS DP5 OD033412Robert Wood Johnson Foundation (RWJF) Harold Amos Medical Facutly Develoopment ProgramU.S. Department of Veterans Affairs (VA) I01-BX002196U.S. Department of Veterans Affairs (VA) VA Merit Award 00507969
Abstract
We have previously shown that kidney collecting ducts make vasopressin. However, the physiological role of collecting duct-derived vasopressin is uncertain. We hypothesized that collecting duct-derived vasopressin is required for the appropriate concentration of urine. We developed a vasopressin conditional knockout (KO) mouse model wherein Cre recombinase expression induces deletion of arginine vasopressin (
Indexed as
Deamino Arginine VasopressinKidney Tubules, CollectingMice, KnockoutAnimalsAntidiuretic AgentsAntidiuretic Hormone Receptor AntagonistsAquaporin 2Arginine VasopressinBenzazepinesKidney Concentrating AbilityMaleMiceMice, Inbred C57BLOsmolar ConcentrationReceptors, VasopressinSodiumAntidiuretic AgentsAntidiuretic Hormone Receptor AntagonistsAquaporin 2Arginine VasopressinBenzazepinesDeamino Arginine VasopressinmozavaptanReceptors, VasopressinSodiumVasopressinsaquaporin-2desmopressinkidney-derived vasopressinvasopressin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.