ArticleFrontiers in medicine2024
Utilization of a Meningitis/Encephalitis PCR panel at the University Hospital Basel - a retrospective study to develop a diagnostic decision rule.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Optimized use of the FilmArray Meningitis/Encephalitis panel for early discontinuation of antibiotic therapy.Microbiology spectrum · 2026Article
- Utility and clinical relevance of multiplex PCR panels for diagnosis of central nervous system infections.The Indian journal of medical research · 2026Article
- Bridging the diagnostic gap: the role of culture methods in the era of syndromic panels for central nervous system infections.Frontiers in cellular and infection microbiology · 2026Article
- Observational quality control study: insourcing multi-PCR-impact on the use of anti-infectives for patients with pleocytosis.Neurological research and practice · 2025Article
- Performance Evaluation of Multiplex Molecular Syndromic Panel vs. Singleplex PCR for Diagnosis of Acute Central Nervous System Infections.Microorganisms · 2025Article
- Prospective evaluation of real-world performance and clinical impact of the Biofire FilmArray joint infection panel.Microbiology spectrum · 2025Article
- A successful diagnostic case of Varicella zoster virus pneumonia by a Film Array assay for meningitis/encephalitis.Respiratory medicine case reports · 2025Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The Biofire Materials: Adult patients, who underwent CSF analysis with the ME panel between August 2016 and June 2021 at the University Hospital Basel, were included. Demographic, clinical, microbiological, and laboratory data were extracted from the electronic health record. Factors associated with a positive ME panel result were identified, and a decision rule was developed to potentially optimize the diagnostic yield and reduce the number of unnecessary tests. Results: 1,236 adult patients received at least one panel in the observed period, of whom 106 panels tested positive (8.6%). The most frequently observed pathogens were Varicella Zoster Virus (VZV, 27%), Conclusion: The ME panel positivity rate at our institution was similar as previously published. Our results highlight the need for diagnostic-stewardship interventions when utilizing this assay by implementing a stepwise approach based on a limited number of clinical and laboratory features. This decision rule may improve the pretest probability of a positive test result, increase the quality of test utilization, and reduce costs.
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