Evidence map›Paper›PMID 38694996›Full record

ArticleJACC. Advances2024

TAVR in Older Adults: Moving Toward a Comprehensive Geriatric Assessment and Away From Chronological Age:

Abdulla A Damluji, Gwen Bernacki, Jonathan Afilalo, Radmila Lyubarova, Ariela R Orkaby, Min Ji Kwak, Scott Hummel, James N Kirkpatrick, Mathew S Maurer, Nanette Wenger and 5 more

Abstract read
In one paragraph

Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Abdulla A DamlujiInova Heart and Vascular Institute, Inova Center of Outcomes Research, Falls Church, Virginia, USA.
Gwen BernackiCambia Palliative Care Center of Excellence, University of Washington, Seattle, Washington, USA.
Jonathan AfilaloDepartment of Medicine/Cardiology, McGill University, Montreal, Canada.
Radmila LyubarovaDepartment of Medicine/Cardiology, Albany Medical College, Albany, New York, USA.
Ariela R OrkabyNew England GRECC, VA Boston Healthcare System, Boston, Massachusetts, USA.
Min Ji KwakDivision of Geriatric and Palliative Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Scott HummelDivision of Cardiology, University of Michigan, Ann Arbor, Michigan, USA.
James N KirkpatrickDivision of Cardiology and Department of Bioethics and Humanities, University of Washington School of Medicine, Seattle, Washington, USA.
Mathew S MaurerDivision of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.
Nanette WengerDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Michael W RichCardiovascular Division, Washington University School of Medicine, St. Louis, Missouri, USA.
Dae Hyun KimMarcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, USA.
Roberta Y WangDepartment of Physical Medicine & Rehabilitation, Santa Clara Valley Medical Center, San Jose, California, USA.
Daniel E FormanDepartment of Medicine (Divisions of Cardiology and Geriatrics) and Pittsburgh GRECC, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ashok KrishnaswamiDivision of Cardiology, Kaiser Permanente, San Jose Medical Center, San Jose, California, USA.

Funding

PREVENTABLE Vanguard PhaseU19AG065188 · NIA · DUKE UNIVERSITY · PI KAREN P ALEXANDER · 2019 to 2026
$96.2M
Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF TrialR01AG078153 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2022 to 2025
$26.6M
SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear imaging in Minority Populations) COVID-19 SuppplementR01HL139671 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S, RUBERG, FREDERICK LIEF · 2019 to 2023
$7.4M
Modified Application of Cardiac Rehabilitation (CR) for Older Adults (MACRO)R01AG060499 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORMAN, DANIEL E. · 2018 to 2022
$5.0M
Home-based cardiac rehabilitation using a novel mobile health exercise regimen following transcatheter heart valve interventions (HOME RUN HITTER)R01AG073633 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Brian Richard Lindman · 2022 to 2026
$3.2M
Kidney Injury in Patients with Acute Decompensated Heart FailureR01DK121800 · NIDDK · UNIVERSITY OF WASHINGTON · PI BANSAL, NISHA · 2020 to 2024
$3.2M
Improving outcomes from cardiac rehabilitation among older adults through exercise testing and individualized exercise intensity prescriptionsR01AG077179 · NIA · BAYSTATE MEDICAL CENTER, INC. · PI Quinn Russell Pack · 2022 to 2026
$2.9M
Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac AmyloidosisR01AG081582 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATHEW S MAURER · 2023 to 2026
$2.8M
Nitrite therapy to improve mitochondrial energetics and physical activity in older adultsR01AG058883 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORMAN, DANIEL E. · 2019 to 2021
$2.0M
Frailty and Resiliency in Older Adults with Acute Myocardial InfarctionK23HL153771 · NHLBI · INOVA HEALTH CARE SERVICES · PI DAMLUJI, ABDULLA AL · 2020 to 2024
$916k
CSRD VA IK2 CX001800HSRD VA I01 HX003518NHLBI NIH HHS K23 HL153771NHLBI NIH HHS R01 HL139671NIA NIH HHS P30 AG021334NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG058883NIA NIH HHS R01 AG060499NIA NIH HHS R01 AG073633NIA NIH HHS R01 AG077179NIA NIH HHS R01 AG078153NIA NIH HHS R01 AG081582NIA NIH HHS U19 AG065188NIDDK NIH HHS R01 DK121800Patient-Centered Outcomes Research Institute IHS-2021C3-24147RRD VA I21 RX004409
6 · The paper itself

Abstract

Calcific aortic stenosis can be considered a model for geriatric cardiovascular conditions due to a confluence of factors. The remarkable technological development of transcatheter aortic valve replacement was studied initially on older adult populations with prohibitive or high-risk for surgical valve replacement. Through these trials, the cardiovascular community has recognized that stratification of these chronologically older adults can be improved incrementally by invoking the concept of frailty and other geriatric risks. Given the complexity of the aging process, stratification by chronological age should only be the initial step but is no longer sufficient to optimally quantify cardiovascular and noncardiovascular risk. In this review, we employ a geriatric cardiology lens to focus on the diagnosis and the comprehensive management of aortic stenosis in older adults to enhance shared decision-making with patients and their families and optimize patient-centered outcomes. Finally, we highlight knowledge gaps that are critical for future areas of study.

Indexed as

agingbiological agecalcific aortic stenosischronological agecognitive functionfrailtypatient-centered outcomesphysical functionphysiological agequality of lifeTAVR

Identifiers

PMID38694996
PMCPMC11062620

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.