ArticleFrontiers in pharmacology2024
Hippocampal region metabolites and cognitive impairment in patients with general paresis: based on
Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.
- Association between spirochaetal infection and neurodegenerative diseases: a systematic review and quantitative synthesis of observational studies.Journal of medical microbiology · 2026Pooled it
- A Pilot Study of Brain Metabolites and Their Diagnostic Cutoff Point in Postmenopausal Women With Cognitive Impairment Using Magnetic Resonance Spectroscopy.NMR in biomedicine · 2026Article
- Alterations of cognitive function and hippocampal metabolism in asymptomatic neurosyphilis patients: based onFrontiers in neurologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study utilizes Hydrogen proton magnetic resonance spectroscopy ( Methods: A total of 80 GP patients and 57 normal controls (NCs) were enrolled. Metabolite ratios in the bilateral hippocampus were measured using Results: MMSE scores progressively decreased in the normal, mild cognitive impairment, and moderate-severe dementia groups ( Conclusion: There are distinctive metabolic characteristics in the hippocampus of GP patients. GP patients exhibited lower NAA/Cr and NAA/Cho ratios in the bilateral hippocampus, indicating neuron loss in these areas, which may become more pronounced as the disease progresses.
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Registered trials
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