Evidence map›Paper›PMID 38694904›Full record

ArticleSAGE open medical case reports2024

A case series on safety and tolerability of human umbilical cord-derived mesenchymal stem cells on patients in Malaysia.

Basmullah Yusof, Iqmaliza Kamal, Ka Man Lee, Siong Kiat Chai, Xia Lin Zuo, Manickam Ravichandran, Ke Xiang Ding, Neeraj Kumar Fuloria, Seng Kong Tham

Abstract readCase Reports
In one paragraph

Article in SAGE open medical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Basmullah YusofALPS Medical Centre, ALPS Global Holding, Kuala Lumpur, Malaysia.
Iqmaliza KamalCelestialab Sdn Bhd, Kuala Lumpur, Malaysia.
Ka Man LeeCelestialab Sdn Bhd, Kuala Lumpur, Malaysia.
Siong Kiat ChaiCelestialab Sdn Bhd, Kuala Lumpur, Malaysia.
Xia Lin ZuoALPS Medical Centre, ALPS Global Holding, Kuala Lumpur, Malaysia.
Manickam RavichandranMygenome, ALPS Global Holding, Kuala Lumpur, Malaysia.
Ke Xiang DingALPS Medical Centre, ALPS Global Holding, Kuala Lumpur, Malaysia.
Neeraj Kumar FuloriaFaculty of Pharmacy, AIMST University, Kedah, Malaysia.ORCID https://orcid.org/0000-0002-8970-5212
Seng Kong ThamALPS Global Holding Berhad, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Umbilical cord-derived mesenchymal stem cells for regenerative therapy are a promising treatment option for chronic illnesses. Umbilical cord-derived mesenchymal stem cells offer several advantages over other sources, which makes them an attractive option in tissue repair and regeneration. This clinical study describes a 1-year follow-up on the safety and tolerance of umbilical cord-derived mesenchymal stem cell therapy on nine patients in Malaysia. Patients were assessed for adverse effects, and liver function tests were carried out on both pre- and post-treatments. Umbilical cord-derived mesenchymal stem cells' effectiveness and safety were assessed by follow-up evaluations. All nine patients responded positively towards umbilical cord-derived mesenchymal stem cell therapy, without any adverse effects. After umbilical cord-derived mesenchymal stem cell therapy, a significant improvement was observed in liver functioning test outcomes, as haematological parameters and tumour markers were stable. The present study concludes that umbilical cord-derived mesenchymal stem cell therapy is well tolerated by Malaysian patients; however, further clinical screening must be done over a large number of patients population.

Indexed as

chronic diseaseslivermesenchymal stem cellsregenerationregenerative therapyUmbilical cord-derived

Identifiers

PMID38694904
PMCPMC11062224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.