Evidence map›Paper›PMID 38694891›Full record

ArticleAPL bioengineering2024

Investigating cartilage-related diseases by polarization-resolved second harmonic generation (P-SHG) imaging.

Kausalya Neelavara Makkithaya, Nirmal Mazumder, Wei-Hsun Wang, Wei-Liang Chen, Ming-Chi Chen, Ming-Xin Lee, Chin-Yu Lin, Yung-Ju Yeh, Gregory J Tsay, Sitaram Chopperla and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Kausalya Neelavara MakkithayaDepartment of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.ORCID https://orcid.org/0009-0006-5552-3767
Nirmal MazumderDepartment of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.ORCID https://orcid.org/0000-0001-8068-6484
Wei-Hsun WangInstitute of Translational Medicine and New Drug Development, China Medical University, Taichung 404328, Taiwan.ORCID https://orcid.org/0000-0003-2131-8651
Wei-Liang ChenCenter for Condensed Matter Sciences, National Taiwan University, Taipei 10617, Taiwan.ORCID https://orcid.org/0000-0001-9256-1435
Ming-Chi ChenInstitute of Translational Medicine and New Drug Development, China Medical University, Taichung 404328, Taiwan.ORCID https://orcid.org/0000-0003-0934-8671
Ming-Xin LeeInstitute of Translational Medicine and New Drug Development, China Medical University, Taichung 404328, Taiwan.ORCID https://orcid.org/0000-0002-8807-3452
Chin-Yu LinDepartment of Biomedical Sciences and Engineering, Tzu Chi University, Hualien 97004, Taiwan.ORCID https://orcid.org/0000-0003-2304-7381
Yung-Ju YehAutoimmune Disease Laboratory, China Medical University Hospital, Taichung 404327, Taiwan.ORCID https://orcid.org/0000-0001-8263-1532
Gregory J TsayORCID https://orcid.org/0000-0003-3817-8229
Sitaram ChopperlaDepartment of Orthopedics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.ORCID https://orcid.org/0000-0003-3499-1570
Krishna Kishore MahatoDepartment of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.ORCID https://orcid.org/0000-0001-9873-3445
Fu-Jen KaoInstitute of Biophotonics, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID https://orcid.org/0000-0001-8361-3942
Guan-Yu ZhuoInstitute of Translational Medicine and New Drug Development, China Medical University, Taichung 404328, Taiwan.ORCID https://orcid.org/0000-0002-9813-2989
China Medical University · TWManipal Academy of Higher Education · INNational Taiwan University · TWNational Yang Ming Chiao Tung University · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Establishing quantitative parameters for differentiating between healthy and diseased cartilage tissues by examining collagen fibril degradation patterns facilitates the understanding of tissue characteristics during disease progression. These findings could also complement existing clinical methods used to diagnose cartilage-related diseases. In this study, cartilage samples from normal, osteoarthritis (OA), and rheumatoid arthritis (RA) tissues were prepared and analyzed using polarization-resolved second harmonic generation (P-SHG) imaging and quantitative image texture analysis. The enhanced molecular contrast obtained from this approach is expected to aid in distinguishing between healthy and diseased cartilage tissues. P-SHG image analysis revealed distinct parameters in the cartilage samples, reflecting variations in collagen fibril arrangement and organization across different pathological states. Normal tissues exhibited distinct

Identifiers

PMID38694891
PMCPMC11062753
OpenAlexW4396512297

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.