Evidence map›Paper›PMID 38694760›Full record

ArticleArchives of internal medicine research2024

African Americans Possessed High Prevalence of Comorbidities and Frequent Abdominal Symptoms, and Comprised A Disproportionate Share of Covid-19 Mortality among 9,873 Us- Hospitalized Patients Early in the Pandemic.

Hassan Ashktorab, Antonio Pizuorno, Lakshmi Gayathri Chirumamilla, Folake Adeleye, Maryam Mehdipour Dalivand, Zaki A Sherif, Gholamreza Oskrochi, Suryanarayana Reddy Challa, Boubini Jones-Wonni, Sheldon Rankine and 34 more

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Article in Archives of internal medicine research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 1 institution in 1 country.

Hassan AshktorabDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Antonio PizuornoDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Lakshmi Gayathri ChirumamillaDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Folake AdeleyeDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Maryam Mehdipour DalivandDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Zaki A SherifDepartment of Pathology and Cancer Center, Department of Biochemistry & Molecular Biology, Howard University College of Medicine, Washington DC, USA.
Gholamreza OskrochiCollege of Engineering and Technology, American University of the Middle East, Kuwait.
Suryanarayana Reddy ChallaDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Boubini Jones-WonniDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Sheldon RankineDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Chiamaka EkwunazuDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Abigail BansonDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Rachel KimDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Chandler GilliardDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Elizabeth EkpeDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Nader ShayeghDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Constance NyaunuDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Chidi MartinsDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Ashley SlackDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Princess OkwesiliDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Malachi AbebeDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Yashvardhan BattaDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Do LyDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Ogwo ValarieDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Tori SmithDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Kyra WatsonDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Oluwapelumi KolawoleDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Sarine TahmazianDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Sofiat AtobaDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Myra KhushbakhtDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Gregory RileyDepartment of Medicine, GI Division, Cancer Center, Howard University Hospital, Washington DC, USA.
Warren GavinDivision of General Internal Medicine and Geriatrics, Indiana University School of Medicine, IN, USA.
Areeba KaraDivision of General Internal Medicine and Geriatrics, Indiana University School of Medicine, IN, USA.
Manuel Hache-MarliereDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Leonidas PalaiodimosDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Vishnu R ManiDepartment of Trauma, Acute and Critical Care Surgery, Duke University Medical Center, NC, USA.
Aleksandr KalabinDepartment of Surgery, Columbia University College of Physicians and Surgeons at Harlem Hospital, NY, USA.
Vijay Reddy GayamDepartment of Medicine, Interfaith Medical Center, NY, USA.
Pavani Reddy GarlapatiDepartment of Medicine, Interfaith Medical Center, NY, USA.
Joseph MillerDepartments of Emergency Medicine and Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Fatimah JacksonDepartment of Pathology and Cancer Center, Department of Biochemistry & Molecular Biology, Howard University College of Medicine, Washington DC, USA.
John M CarethersDivision of Gastroenterology and Hepatology, Department of Internal Medicine; Department of Human Genetics and Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Vinod RustgiDivision of Gastroenterology and Hepatology, Robert Wood Johnson University Hospital - New Brunswick, NJ.
Hassan BrimDepartment of Pathology and Cancer Center, Department of Biochemistry & Molecular Biology, Howard University College of Medicine, Washington DC, USA.
Howard University Hospital · US

Funding

PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
Inactivation of MSH3 in Colorectal Cancer and RaceR01CA258519 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASHKTORAB, HASSAN, CARETHERS, JOHN M · 2021 to 2025
$2.9M
NCI NIH HHS R01 CA258519NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

Background and aim: Identifying clinical characteristics and outcomes of different ethnicities in the US may inform treatment for hospitalized COVID-19 patients. Aim of this study is to identify predictors of mortality among US races/ethnicities. Design Setting and participants: We retrospectively analyzed de-identified data from 9,873 COVID-19 patients who were hospitalized at 15 US hospital centers in 11 states (March 2020-November 2020). Main Outcomes and Measures: The primary outcome was to identify predictors of mortality in hospitalized COVID-19 patients. Results: Among the 9,873 patients, there were 64.1% African Americans (AA), 19.8% Caucasians, 10.4% Hispanics, and 5.7% Asians, with 50.7% female. Males showed higher in-hospital mortality (20.9% vs. 15.3%, p=0.001). Non- survivors were significantly older (67 vs. 61 years) than survivors. Patients in New York had the highest in-hospital mortality (OR=3.54 (3.03 - 4.14)). AA patients possessed higher prevalence of comorbidities, had longer hospital stay, higher ICU admission rates, increased requirement for mechanical ventilation and higher in-hospital mortality compared to other races/ethnicities. Gastrointestinal symptoms (GI), particularly diarrhea, were more common among minority patients. Among GI symptoms and laboratory findings, abdominal pain (5.3%, p=0.03), elevated AST (n=2653, 50.2%, p=<0.001, OR=2.18), bilirubin (n=577, 12.9%, p=0.01) and low albumin levels (n=361, 19.1%, p=0.03) were associated with mortality. Multivariate analysis (adjusted for age, sex, race, geographic location) indicates that patients with asthma, COPD, cardiac disease, hypertension, diabetes mellitus, immunocompromised status, shortness of breath and cough possess higher odds of in-hospital mortality. Among laboratory parameters, patients with lymphocytopenia (OR2=2.50), lymphocytosis (OR2=1.41), and elevations of serum CRP (OR2=4.19), CPK (OR2=1.43), LDH (OR2=2.10), troponin (OR2=2.91), ferritin (OR2=1.88), AST (OR2=2.18), D-dimer (OR2=2.75) are more prone to death. Patients on glucocorticoids (OR2=1.49) and mechanical ventilation (OR2=9.78) have higher in-hospital mortality. Conclusion: These findings suggest that older age, male sex, AA race, and hospitalization in New York were associated with higher in-hospital mortality rates from COVID-19 in early pandemic stages. Other predictors of mortality included the presence of comorbidities, shortness of breath, cough elevated serum inflammatory markers, altered lymphocyte count, elevated AST, and low serum albumin. AA patients comprised a disproportionate share of COVID-19 death in the US during 2020 relative to other races/ethnicities.

Indexed as

African AmericansCOVID-19MortalityUnited States

Identifiers

PMID38694760
PMCPMC11062622
OpenAlexW4392403284

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.