Evidence map›Paper›PMID 38694643›Full record

ArticleCureus2024

Euphoric Presentation in Creutzfeldt-Jakob Disease and Its Diagnostic Implications: A Case Report.

Mark Sahyouni, Bradley Casey, Zachary Carpenter, Frank Estrella, Chika Okafor

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark SahyouniInternal Medicine, Campbell University School of Osteopathic Medicine, Buies Creek, USA.
Bradley CaseyInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
Zachary CarpenterInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
Frank EstrellaInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.
Chika OkaforInternal Medicine, Cape Fear Valley Medical Center, Fayetteville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Creutzfeldt-Jakob disease (CJD) constitutes an aggressively advancing, terminal neurodegenerative condition classified within the spectrum of transmissible spongiform encephalopathies. The difficulty in establishing a diagnosis before death arises from the condition's rarity and the resulting limited level of suspicion attributed to it. The polymorphic nature of CJD symptoms contributes to the challenge of early diagnostic recognition. Emotional and behavioral changes have been well documented, but the initial presentation of euphoria has not been documented. Here, we present the case of a female patient who was experiencing an unusual state of euphoria followed by intermittently altered mental status. She was ultimately diagnosed with sporadic CJD, discharged home on hospice, and died within six months of discharge.

Indexed as

14-3-3 gammacerebrospinal fluid biomarkercognitive deteriorationcreutzfeldt-jakob diseaseeuphoriahuman prion disease

Identifiers

PMID38694643
PMCPMC11062774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.